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@ARTICLE{DelaCruz:890795,
      author       = {De-la-Cruz, I. M. and Hallab, A. and Olivares-Pinto, U. and
                      Tapia-López, R. and Velázquez-Márquez, S. and Piñero, D.
                      and Oyama, K. and Usadel, B. and Núñez-Farfán, J.},
      title        = {{G}enomic signatures of the evolution of defence against
                      its natural enemies in the poisonous and medicinal plant
                      {D}atura stramonium ({S}olanaceae)},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-01203},
      pages        = {882},
      year         = {2021},
      note         = {Grant name:Fronteras de la Ciencia” Grant (#1527)PAPIIT,
                      UNAM Grant (PAPIIT-DGAPA AG200717)},
      abstract     = {Tropane alkaloids and terpenoids are widely used in the
                      medicine and pharmaceutic industry and evolved as chemical
                      defenses against herbivores and pathogens in the annual herb
                      Datura stramonium (Solanaceae). Here, we present the first
                      draft genomes of two plants from contrasting environments of
                      D. stramonium. Using these de novo assemblies, along with
                      other previously published genomes from 11 Solanaceae
                      species, we carried out comparative genomic analyses to
                      provide insights on the genome evolution of D. stramonium
                      within the Solanaceae family, and to elucidate adaptive
                      genomic signatures to biotic and abiotic stresses in this
                      plant. We also studied, in detail, the evolution of four
                      genes of D. stramonium—Putrescine N-methyltransferase,
                      Tropinone reductase I, Tropinone reductase II and
                      Hyoscyamine-6S-dioxygenase—involved in the tropane
                      alkaloid biosynthesis. Our analyses revealed that the
                      genomes of D. stramonium show signatures of expansion,
                      physicochemical divergence and/or positive selection on
                      proteins related to the production of tropane alkaloids,
                      terpenoids, and glycoalkaloids as well as on R defensive
                      genes and other important proteins related with biotic and
                      abiotic pressures such as defense against natural enemies
                      and drought.},
      cin          = {IBG-4},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBG-4-20200403},
      pnm          = {217 - Für eine nachhaltige Bio-Ökonomie – von
                      Ressourcen zu Produkten (POF4-217)},
      pid          = {G:(DE-HGF)POF4-217},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33441607},
      UT           = {WOS:000621765000035},
      doi          = {10.1038/s41598-020-79194-1},
      url          = {https://juser.fz-juelich.de/record/890795},
}