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@ARTICLE{Tohge:890803,
      author       = {Tohge, Takayuki and Scossa, Federico and Wendenburg, Regina
                      and Frasse, Pierre and Balbo, Ilse and Watanabe, Mutsumi and
                      Alseekh, Saleh and Jadhav, Sagar Sudam and Delfin, Jay C.
                      and Lohse, Marc and Giavalisco, Patrick and Usadel, Björn
                      and Zhang, Youjun and Luo, Jie and Bouzayen, Mondher and
                      Fernie, Alisdair R.},
      title        = {{E}xploiting {N}atural {V}ariation in {T}omato to {D}efine
                      {P}athway {S}tructure and {M}etabolic {R}egulation of
                      {F}ruit {P}olyphenolics in the {L}ycopersicum {C}omplex},
      journal      = {Molecular plant},
      volume       = {13},
      number       = {7},
      issn         = {1674-2052},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2021-01211},
      pages        = {1027 - 1046},
      year         = {2020},
      abstract     = {While the structures of plant primary metabolic pathways
                      are generally well defined and highly conserved across
                      species, those defining specialized metabolism are less well
                      characterized and more highly variable across species. In
                      this study, we investigated polyphenolic metabolism in the
                      lycopersicum complex by characterizing the underlying
                      biosynthetic and decorative reactions that constitute the
                      metabolic network of polyphenols across eight different
                      species of tomato. For this purpose, GC–MS- and
                      LC–MS-based metabolomics of different tissues of Solanum
                      lycopersicum and wild tomato species were carried out, in
                      concert with the evaluation of cross-hybridized microarray
                      data for MapMan-based transcriptomic analysis, and publicly
                      available RNA-sequencing data for annotation of biosynthetic
                      genes. The combined data were used to compile
                      species-specific metabolic networks of polyphenolic
                      metabolism, allowing the establishment of an entire
                      pan-species biosynthetic framework as well as annotation of
                      the functions of decoration enzymes involved in the
                      formation of metabolic diversity of the flavonoid pathway.
                      The combined results are discussed in the context of the
                      current understanding of tomato flavonol biosynthesis as
                      well as a global view of metabolic shifts during fruit
                      ripening. Our results provide an example as to how
                      large-scale biology approaches can be used for the
                      definition and refinement of large specialized metabolism
                      pathways.},
      cin          = {IBG-4},
      ddc          = {580},
      cid          = {I:(DE-Juel1)IBG-4-20200403},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32305499},
      UT           = {WOS:000547375600012},
      doi          = {10.1016/j.molp.2020.04.004},
      url          = {https://juser.fz-juelich.de/record/890803},
}