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@ARTICLE{Jockwitz:890804,
author = {Jockwitz, Christiane and Caspers, S.},
title = {{R}esting-state networks in the course of
aging—differential insights from studies across the
lifespan vs. amongst the old},
journal = {PfluÌgers Archiv},
volume = {473},
issn = {1432-2013},
address = {Heidelberg},
publisher = {Springer},
reportid = {FZJ-2021-01212},
pages = {793–803},
year = {2021},
abstract = {Resting-state functional connectivity (RSFC) has widely
been used to examine reorganization of functional brain
networks during normal aging. The extraction of
generalizable age trends, however, is hampered by
differences in methodological approaches, study designs and
sample characteristics. Distinct age ranges of study samples
thereby represent an important aspect between studies
especially due to the increase in inter-individual
variability over the lifespan. The current review focuses on
comparing age-related differences in RSFC in the course of
the whole adult lifespan versus later decades of life. We
summarize and compare studies assessing age-related
differences in within- and between-network RSFC of major
resting-state brain networks. Differential effects of the
factor age on resting-state networks can be identified when
comparing studies focusing on younger versus older adults
with studies investigating effects within the older adult
population. These differential effects pertain to higher
order and primary processing resting-state networks to a
varying extent. Especially during later decades of life,
other factors beyond age might come into play to understand
the high inter-individual variability in RSFC.},
cin = {INM-1},
ddc = {590},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {525 - Decoding Brain Organization and Dysfunction
(POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
Agreement 3 (945539)},
pid = {G:(DE-HGF)POF4-525 / G:(EU-Grant)945539},
typ = {PUB:(DE-HGF)16},
pubmed = {33576851},
UT = {WOS:000617490400001},
doi = {10.1007/s00424-021-02520-7},
url = {https://juser.fz-juelich.de/record/890804},
}