TY  - JOUR
AU  - Choi, Chang-Hoon
AU  - Iordanishvili, Elene
AU  - Shah, N. J.
AU  - Binkofski, Ferdinand
TI  - Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review
JO  - Human brain mapping
VL  - 42
IS  - 8
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - FZJ-2021-01226
SP  - 2642-2671
PY  - 2021
AB  - A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. A favourable approach enabling the modulation of neuronal excitability and energy in humans is to stimulate the brain using transcranial direct current stimulation (tDCS) and then to observe the effect on neurometabolites using magnetic resonance spectroscopy (MRS). In this way, a well‐defined modulation of brain energy and excitability can be achieved using a dedicated tDCS protocol to a predetermined brain region. This systematic review was guided by the preferred reporting items for systematic reviews and meta‐analysis and summarises recent literature studying the effect of tDCS on neurometabolites in the human brain as measured by proton or phosphorus MRS. Limitations and recommendations are discussed for future research. The findings of this review provide clear evidence for the potential of using tDCS and MRS to examine and understand the effect of neurometabolites in the in vivo human brain.
LB  - PUB:(DE-HGF)16
C6  - 33634527
UR  - <Go to ISI:>//WOS:000621751000001
DO  - DOI:10.1002/hbm.25388
UR  - https://juser.fz-juelich.de/record/890895
ER  -