000891302 001__ 891302 000891302 005__ 20220116012945.0 000891302 0247_ $$2doi$$a10.3390/v13030504 000891302 0247_ $$2Handle$$a2128/27456 000891302 0247_ $$2pmid$$a33803830 000891302 0247_ $$2WOS$$aWOS:000634204700001 000891302 0247_ $$2altmetric$$aaltmetric:120278226 000891302 037__ $$aFZJ-2021-01409 000891302 082__ $$a050 000891302 1001_ $$00000-0001-7049-9458$$aJaguva Vasudevan, Ananda Ayyappan$$b0$$eCorresponding author 000891302 245__ $$aFoamy Viruses, Bet, and APOBEC3 Restriction 000891302 260__ $$aBasel$$bMDPI$$c2021 000891302 3367_ $$2DRIVER$$aarticle 000891302 3367_ $$2DataCite$$aOutput Types/Journal article 000891302 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1641839560_26014 000891302 3367_ $$2BibTeX$$aARTICLE 000891302 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000891302 3367_ $$00$$2EndNote$$aJournal Article 000891302 520__ $$aNon-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called foamy viruses (FV) with zoonotic potential are occasionally detected in bushmeat hunters or zookeepers. Various FVs are endemic in numerous mammalian natural hosts, such as primates, felines, bovines, and equines, and other animals, but not in humans. They are apathogenic, and significant differences exist between the viral life cycles of FV and other retroviruses. Importantly, FVs replicate in the presence of many well-defined retroviral restriction factors such as TRIM5α, BST2 (Tetherin), MX2, and APOBEC3 (A3). While the interaction of A3s with HIV-1 is well studied, the escape mechanisms of FVs from restriction by A3 is much less explored. Here we review the current knowledge of FV biology, host restriction factors, and FV–host interactions with an emphasis on the consequences of FV regulatory protein Bet binding to A3s and outline crucial open questions for future studies. 000891302 536__ $$0G:(DE-HGF)POF4-5111$$a5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511)$$cPOF4-511$$fPOF IV$$x0 000891302 536__ $$0G:(DE-Juel1)hkf7_20200501$$aForschergruppe Gohlke (hkf7_20200501)$$chkf7_20200501$$fForschergruppe Gohlke$$x1 000891302 588__ $$aDataset connected to CrossRef 000891302 7001_ $$0P:(DE-HGF)0$$aBecker, Daniel$$b1 000891302 7001_ $$0P:(DE-HGF)0$$aLuedde, Tom$$b2 000891302 7001_ $$0P:(DE-Juel1)172663$$aGohlke, Holger$$b3 000891302 7001_ $$0P:(DE-HGF)0$$aMünk, Carsten$$b4$$eCorresponding author 000891302 773__ $$0PERI:(DE-600)2516098-9$$a10.3390/v13030504$$gVol. 13, no. 3, p. 504 -$$n3$$p504$$tViruses$$v13$$x1999-4915$$y2021 000891302 8564_ $$uhttps://juser.fz-juelich.de/record/891302/files/viruses-13-00504-v2.pdf$$yOpenAccess 000891302 909CO $$ooai:juser.fz-juelich.de:891302$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire 000891302 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)172663$$aForschungszentrum Jülich$$b3$$kFZJ 000891302 9131_ $$0G:(DE-HGF)POF4-511$$1G:(DE-HGF)POF4-510$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5111$$aDE-HGF$$bKey Technologies$$lEngineering Digital Futures – Supercomputing, Data Management and Information Security for Knowledge and Action$$vEnabling Computational- & Data-Intensive Science and Engineering$$x0 000891302 9130_ $$0G:(DE-HGF)POF3-511$$1G:(DE-HGF)POF3-510$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lSupercomputing & Big Data$$vComputational Science and Mathematical Methods$$x0 000891302 9141_ $$y2021 000891302 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0 000891302 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bVIRUSES-BASEL : 2018$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess 000891302 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-09-02 000891302 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-09-02 000891302 920__ $$lyes 000891302 9201_ $$0I:(DE-Juel1)JSC-20090406$$kJSC$$lJülich Supercomputing Center$$x0 000891302 9201_ $$0I:(DE-Juel1)NIC-20090406$$kNIC$$lJohn von Neumann - Institut für Computing$$x1 000891302 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x2 000891302 980__ $$ajournal 000891302 980__ $$aVDB 000891302 980__ $$aI:(DE-Juel1)JSC-20090406 000891302 980__ $$aI:(DE-Juel1)NIC-20090406 000891302 980__ $$aI:(DE-Juel1)IBI-7-20200312 000891302 980__ $$aUNRESTRICTED 000891302 9801_ $$aFullTexts