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@ARTICLE{JaguvaVasudevan:891302,
      author       = {Jaguva Vasudevan, Ananda Ayyappan and Becker, Daniel and
                      Luedde, Tom and Gohlke, Holger and Münk, Carsten},
      title        = {{F}oamy {V}iruses, {B}et, and {APOBEC}3 {R}estriction},
      journal      = {Viruses},
      volume       = {13},
      number       = {3},
      issn         = {1999-4915},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-01409},
      pages        = {504},
      year         = {2021},
      abstract     = {Non-human primates (NHP) are an important source of viruses
                      that can spillover to humans and, after adaptation, spread
                      through the host population. Whereas HIV-1 and HTLV-1
                      emerged as retroviral pathogens in humans, a unique class of
                      retroviruses called foamy viruses (FV) with zoonotic
                      potential are occasionally detected in bushmeat hunters or
                      zookeepers. Various FVs are endemic in numerous mammalian
                      natural hosts, such as primates, felines, bovines, and
                      equines, and other animals, but not in humans. They are
                      apathogenic, and significant differences exist between the
                      viral life cycles of FV and other retroviruses. Importantly,
                      FVs replicate in the presence of many well-defined
                      retroviral restriction factors such as TRIM5α, BST2
                      (Tetherin), MX2, and APOBEC3 (A3). While the interaction of
                      A3s with HIV-1 is well studied, the escape mechanisms of FVs
                      from restriction by A3 is much less explored. Here we review
                      the current knowledge of FV biology, host restriction
                      factors, and FV–host interactions with an emphasis on the
                      consequences of FV regulatory protein Bet binding to A3s and
                      outline crucial open questions for future studies.},
      cin          = {JSC / NIC / IBI-7},
      ddc          = {050},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / Forschergruppe
                      Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF4-5111 / $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33803830},
      UT           = {WOS:000634204700001},
      doi          = {10.3390/v13030504},
      url          = {https://juser.fz-juelich.de/record/891302},
}