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000891310 1001_ $$00000-0002-3338-1845$$aLi, Yongqiang$$b0
000891310 245__ $$aMagnetic graphene quantum dots facilitate closed-tube one-step detection of SARS-CoV-2 with ultra-low field NMR relaxometry
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000891310 520__ $$aThe rapid and sensitive diagnosis of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the crucial issues at the outbreak of the ongoing global pandemic that has no valid cure. Here, we propose a SARS-CoV-2 antibody conjugated magnetic graphene quantum dots (GQDs)-based magnetic relaxation switch (MRSw) that specifically recognizes the SARS-CoV-2. The probe of MRSw can be directly mixed with the test sample in a fully sealed vial without sample pretreatment, which largely reduces the testers’ risk of infection during the operation. The closed-tube one-step strategy to detect SARS-CoV-2 is developed with homemade ultra-low field nuclear magnetic resonance (ULF NMR) relaxometry working at 118 μT. The magnetic GQDs-based probe shows ultra-high sensitivity in the detection of SARS-CoV-2 due to its high magnetic relaxivity, and the limit of detection is optimized to 248 Particles mL‒1. Meanwhile, the detection time in ULF NMR system is only 2 min, which can significantly improve the efficiency of detection. In short, the magnetic GQDs-based MRSw coupled with ULF NMR can realize a rapid, safe, and sensitive detection of SARS-CoV-2.
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000891310 7001_ $$0P:(DE-HGF)0$$aMa, Peixiang$$b1
000891310 7001_ $$0P:(DE-HGF)0$$aTao, Quan$$b2
000891310 7001_ $$0P:(DE-Juel1)128697$$aKrause, Hans-Joachim$$b3$$ufzj
000891310 7001_ $$0P:(DE-HGF)0$$aYang, Siwei$$b4
000891310 7001_ $$0P:(DE-HGF)0$$aDing, Guqiao$$b5$$eCorresponding author
000891310 7001_ $$0P:(DE-HGF)0$$aDong, Hui$$b6$$eCorresponding author
000891310 7001_ $$0P:(DE-HGF)0$$aXie, Xiaoming$$b7
000891310 773__ $$0PERI:(DE-600)1500731-5$$a10.1016/j.snb.2021.129786$$gVol. 337, p. 129786 -$$p129786 -$$tSensors and actuators <Lausanne> / B$$v337$$x0925-4005$$y2021
000891310 8564_ $$uhttps://juser.fz-juelich.de/record/891310/files/Authors%27%20Manuscript%20Final%20Draft%20Post%20Referee.pdf$$yPublished on 2021-03-15. Available in OpenAccess from 2023-03-15.$$zStatID:(DE-HGF)0510
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