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@ARTICLE{Li:891310,
author = {Li, Yongqiang and Ma, Peixiang and Tao, Quan and Krause,
Hans-Joachim and Yang, Siwei and Ding, Guqiao and Dong, Hui
and Xie, Xiaoming},
title = {{M}agnetic graphene quantum dots facilitate closed-tube
one-step detection of {SARS}-{C}o{V}-2 with ultra-low field
{NMR} relaxometry},
journal = {Sensors and actuators / B},
volume = {337},
issn = {0925-4005},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2021-01417},
pages = {129786 -},
year = {2021},
abstract = {The rapid and sensitive diagnosis of the highly contagious
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is one of the crucial issues at the outbreak of the ongoing
global pandemic that has no valid cure. Here, we propose a
SARS-CoV-2 antibody conjugated magnetic graphene quantum
dots (GQDs)-based magnetic relaxation switch (MRSw) that
specifically recognizes the SARS-CoV-2. The probe of MRSw
can be directly mixed with the test sample in a fully sealed
vial without sample pretreatment, which largely reduces the
testers’ risk of infection during the operation. The
closed-tube one-step strategy to detect SARS-CoV-2 is
developed with homemade ultra-low field nuclear magnetic
resonance (ULF NMR) relaxometry working at 118 μT. The
magnetic GQDs-based probe shows ultra-high sensitivity in
the detection of SARS-CoV-2 due to its high magnetic
relaxivity, and the limit of detection is optimized to 248
Particles mL‒1. Meanwhile, the detection time in ULF NMR
system is only 2 min, which can significantly improve the
efficiency of detection. In short, the magnetic GQDs-based
MRSw coupled with ULF NMR can realize a rapid, safe, and
sensitive detection of SARS-CoV-2.},
cin = {IBI-3},
ddc = {620},
cid = {I:(DE-Juel1)IBI-3-20200312},
pnm = {5241 - Molecular Information Processing in Cellular Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5241},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33753963},
UT = {WOS:000640386700002},
doi = {10.1016/j.snb.2021.129786},
url = {https://juser.fz-juelich.de/record/891310},
}