%0 Conference Paper
%A Tan, Zihan
%A Dhont, Jan K.G.
%A Calandrini, Vania
%A Naegele, Gerhard
%T Quasi-two-dimensional diffusion of interacting globular proteins
%M FZJ-2021-01458
%D 2021
%Z *Computing time is granted through JARA-HPC on JURECA at the Forschungszentrum Jülich.
%X Diffusion of proteins along lipid membranes plays a vital role in cell signaling processes. How the collective and self-diffusion of proteins are affected by direct and hydrodynamic interactions is relevant, e.g., for protein clustering and oligomerization of receptor protein subunits. Using mesoscale hydrodynamic simulations, the dynamic predictions by a minimalistic protein-membrane-cytosol model are explored. The model describes globular proteins as Brownian spheres, confined to lateral motion in a planar monolayer embedded in a three-dimensional viscous fluid. The proteins are assumed to interact pairwisely either via a hard-core potential or a soft potential consisting of competing short-range attractive and long-range repulsive parts. We analyze spatio-temporal correlations from short times where inertial motion is resolved up to long times where the solvent-mediated hydrodynamic interactions between proteins are fully developed. In this context, we investigate the short-time buildup of inter-protein hydrodynamic interactions by multiple scattering of sound and vorticity diffusion, and long-time anomalous enhancement of collective diffusion, in their dependence on protein concentration.
%B APS March Meeting 2021
%C 15 Mar 2021 - 19 Mar 2021, Online (USA)
Y2 15 Mar 2021 - 19 Mar 2021
M2 Online, USA
%F PUB:(DE-HGF)6
%9 Conference Presentation
%U https://juser.fz-juelich.de/record/891366