000891366 001__ 891366
000891366 005__ 20210623133500.0
000891366 037__ $$aFZJ-2021-01458
000891366 041__ $$aEnglish
000891366 1001_ $$0P:(DE-Juel1)165875$$aTan, Zihan$$b0$$eCorresponding author$$ufzj
000891366 1112_ $$aAPS March Meeting 2021$$cOnline$$d2021-03-15 - 2021-03-19$$wUSA
000891366 245__ $$aQuasi-two-dimensional diffusion of interacting globular proteins
000891366 260__ $$c2021
000891366 3367_ $$033$$2EndNote$$aConference Paper
000891366 3367_ $$2DataCite$$aOther
000891366 3367_ $$2BibTeX$$aINPROCEEDINGS
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000891366 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1616756869_24004$$xAfter Call
000891366 500__ $$a*Computing time is granted through JARA-HPC on JURECA at the Forschungszentrum Jülich.
000891366 520__ $$aDiffusion of proteins along lipid membranes plays a vital role in cell signaling processes. How the collective and self-diffusion of proteins are affected by direct and hydrodynamic interactions is relevant, e.g., for protein clustering and oligomerization of receptor protein subunits. Using mesoscale hydrodynamic simulations, the dynamic predictions by a minimalistic protein-membrane-cytosol model are explored. The model describes globular proteins as Brownian spheres, confined to lateral motion in a planar monolayer embedded in a three-dimensional viscous fluid. The proteins are assumed to interact pairwisely either via a hard-core potential or a soft potential consisting of competing short-range attractive and long-range repulsive parts. We analyze spatio-temporal correlations from short times where inertial motion is resolved up to long times where the solvent-mediated hydrodynamic interactions between proteins are fully developed. In this context, we investigate the short-time buildup of inter-protein hydrodynamic interactions by multiple scattering of sound and vorticity diffusion, and long-time anomalous enhancement of collective diffusion, in their dependence on protein concentration.
000891366 536__ $$0G:(DE-HGF)POF4-524$$a524 - Molecular and Cellular Information Processing (POF4-524)$$cPOF4-524$$fPOF IV$$x0
000891366 7001_ $$0P:(DE-Juel1)130616$$aDhont, Jan K.G.$$b1$$ufzj
000891366 7001_ $$0P:(DE-Juel1)166168$$aCalandrini, Vania$$b2$$ufzj
000891366 7001_ $$0P:(DE-Juel1)130858$$aNaegele, Gerhard$$b3$$eCorresponding author$$ufzj
000891366 8564_ $$uhttps://meetings.aps.org/Meeting/MAR21/Session/C16.2
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000891366 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)130858$$aForschungszentrum Jülich$$b3$$kFZJ
000891366 9130_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000891366 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
000891366 9141_ $$y2021
000891366 920__ $$lyes
000891366 9201_ $$0I:(DE-Juel1)IBI-4-20200312$$kIBI-4$$lBiomakromolekulare Systeme und Prozesse$$x0
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