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@INPROCEEDINGS{Tan:891366,
author = {Tan, Zihan and Dhont, Jan K.G. and Calandrini, Vania and
Naegele, Gerhard},
title = {{Q}uasi-two-dimensional diffusion of interacting globular
proteins},
reportid = {FZJ-2021-01458},
year = {2021},
note = {*Computing time is granted through JARA-HPC on JURECA at
the Forschungszentrum Jülich.},
abstract = {Diffusion of proteins along lipid membranes plays a vital
role in cell signaling processes. How the collective and
self-diffusion of proteins are affected by direct and
hydrodynamic interactions is relevant, e.g., for protein
clustering and oligomerization of receptor protein subunits.
Using mesoscale hydrodynamic simulations, the dynamic
predictions by a minimalistic protein-membrane-cytosol model
are explored. The model describes globular proteins as
Brownian spheres, confined to lateral motion in a planar
monolayer embedded in a three-dimensional viscous fluid. The
proteins are assumed to interact pairwisely either via a
hard-core potential or a soft potential consisting of
competing short-range attractive and long-range repulsive
parts. We analyze spatio-temporal correlations from short
times where inertial motion is resolved up to long times
where the solvent-mediated hydrodynamic interactions between
proteins are fully developed. In this context, we
investigate the short-time buildup of inter-protein
hydrodynamic interactions by multiple scattering of sound
and vorticity diffusion, and long-time anomalous enhancement
of collective diffusion, in their dependence on protein
concentration.},
month = {Mar},
date = {2021-03-15},
organization = {APS March Meeting 2021, Online (USA),
15 Mar 2021 - 19 Mar 2021},
subtyp = {After Call},
cin = {IBI-4},
cid = {I:(DE-Juel1)IBI-4-20200312},
pnm = {524 - Molecular and Cellular Information Processing
(POF4-524)},
pid = {G:(DE-HGF)POF4-524},
typ = {PUB:(DE-HGF)6},
url = {https://juser.fz-juelich.de/record/891366},
}