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000891416 1001_ $$0P:(DE-HGF)0$$aDippel, Jannik$$b0
000891416 245__ $$aFluid dynamics in pleated membrane filter devices
000891416 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000891416 520__ $$aFluid flow rate and total throughput are the major controlling parameters to calculate the required size of membrane-based filter equipment for manufacturing of pharmaceuticals. Filtration equipment comprises several resistances to flow such as pipes, connectors and the filter construction itself. The incorporated membrane is a main factor that determines the flow rate through the filter element. With larger membrane area, its resistance to flow declines and total filter throughput increases. Yet, additional hydrodynamic resistances in the filter device lead to lower flow rates than expected from the hydrodynamic resistances of the membrane. Especially the membrane pleats and the spacer material in-between can cause additional flow restrictions. This study investigates the causes of these pleat resistances in manufacturing scale filters. First, manufacturing scale filter flow rates were metered to quantify the effects of pleat geometry, filtration pressure and liquid viscosity on pleat resistance. Subsequent computed tomography (CT) scans of filter devices, performed under simulated operating conditions, reveal so far unreported pleat compressions that rise with increasing differential pressure up to 50% at 1.5 bar. In-plane flow resistances of the nonwoven spacer material between the pleats were determined. Finally, these pleat geometries, measured under pressure, and the in-plane nonwoven resistances were implemented into CFD simulations. These simulations show that reduced fluid flow in the nonwoven due to the compression of pleats can explain the previously observed hydrodynamic pleat resistances.
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000891416 7001_ $$0P:(DE-HGF)0$$aHandt, Sebastian$$b1
000891416 7001_ $$0P:(DE-Juel1)128523$$aStute, Birgit$$b2$$ufzj
000891416 7001_ $$0P:(DE-Juel1)129081$$avon Lieres, Eric$$b3$$eCorresponding author$$ufzj
000891416 7001_ $$0P:(DE-HGF)0$$aLoewe, Thomas$$b4
000891416 773__ $$0PERI:(DE-600)2022535-0$$a10.1016/j.seppur.2021.118580$$gVol. 267, p. 118580 -$$p118580 -$$tSeparation and purification technology$$v267$$x1383-5866$$y2021
000891416 8564_ $$uhttps://juser.fz-juelich.de/record/891416/files/Dippel%20et%20al%20manuscript_rev2.pdf$$yPublished on 2021-03-19. Available in OpenAccess from 2023-03-19.$$zStatID:(DE-HGF)0510
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