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@ARTICLE{Comez:891476,
      author       = {Comez, L. and Bianchi, F. and Libera, V. and Longo, M. and
                      Petrillo, C. and Sacchetti, F. and Sebastiani, F. and
                      D’Amico, F. and Rossi, B. and Gessini, A. and
                      Masciovecchio, C. and Amenitsch, H. and Sissi, C. and
                      Paciaroni, A.},
      title        = {{P}olymorphism of human telomeric quadruplexes with drugs:
                      a multi-technique biophysical study},
      journal      = {Physical chemistry, chemical physics},
      volume       = {22},
      number       = {20},
      issn         = {1463-9084},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {FZJ-2021-01550},
      pages        = {11583 - 11592},
      year         = {2020},
      note         = {Kein Post-print vorhanden},
      abstract     = {The human telomeric G-quadruplex structural motif of DNA
                      has come to be known as a new and stimulating target for
                      anticancer drug discovery. Small molecules that interact
                      with G-quadruplex structures in a selective way have gained
                      impressive interest in recent years as they may serve as
                      potential therapeutic agents. Here, we show how circular
                      dichroism, UV resonance Raman and small angle X-ray
                      scattering spectroscopies can be effectively combined to
                      provide insights into structural and molecular aspects of
                      the interaction between human telomeric quadruplexes and
                      ligands. This study focuses on the ability of berberine and
                      palmatine to bind with human telomeric quadruplexes and
                      provides analysis of the conformational landscape visited by
                      the relevant complexes upon thermal unfolding. With
                      increasing temperature, both free and bound G-quadruplexes
                      undergo melting through a multi-state process, populating
                      different intermediate states. Despite the structural
                      similarity of the two ligands, valuable distinctive features
                      characterising their interaction with the G-quadruplex
                      emerged from our multi-technique approach.},
      cin          = {JCNS-FRM-II / JCNS-4 / JCNS-1 / MLZ},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-4-20201012 / I:(DE-Juel1)JCNS-1-20110106 /
                      I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32400802},
      UT           = {WOS:000538039300039},
      doi          = {10.1039/D0CP01483D},
      url          = {https://juser.fz-juelich.de/record/891476},
}