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@ARTICLE{Liu:891633,
      author       = {Liu, Xiaojin and Eickhoff, Simon B. and Caspers, Svenja and
                      Wu, Jianxiao and Genon, Sarah and Hoffstaedter, Felix and
                      Mars, Rogier B. and Sommer, Iris E. and Eickhoff, Claudia R.
                      and Chen, Ji and Jardri, Renaud and Reetz, Kathrin and
                      Dogan, Imis and Aleman, André and Kogler, Lydia and Gruber,
                      Oliver and Caspers, Julian and Mathys, Christian and Patil,
                      Kaustubh R.},
      title        = {{F}unctional parcellation of human and macaque striatum
                      reveals human-specific connectivity in the dorsal caudate},
      journal      = {NeuroImage},
      volume       = {235},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2021-01629},
      pages        = {118006 -},
      year         = {2021},
      abstract     = {A wide homology between human and macaque striatum is often
                      assumed as in both the striatum is involved in cognition,
                      emotion and executive functions. However, differences in
                      functional and structural organization between human and
                      macaque striatum may reveal evolutionary divergence and shed
                      light on human vulnerability to neuropsychiatric diseases.
                      For instance, dopaminergic dysfunction of the human striatum
                      is considered to be a pathophysiological underpinning of
                      different disorders, such as Parkinson's disease (PD) and
                      schizophrenia (SCZ). Previous investigations have found a
                      wide similarity in structural connectivity of the striatum
                      between human and macaque, leaving the cross-species
                      comparison of its functional organization unknown. In this
                      study, resting-state functional connectivity (RSFC) derived
                      striatal parcels were compared based on their homologous
                      cortico-striatal connectivity. The goal here was to identify
                      striatal parcels whose connectivity is human-specific
                      compared to macaque parcels. Functional parcellation
                      revealed that the human striatum was split into dorsal,
                      dorsomedial, and rostral caudate and ventral, central, and
                      caudal putamen, while the macaque striatum was divided into
                      dorsal, and rostral caudate and rostral, and caudal putamen.
                      Cross-species comparison indicated dissimilar
                      cortico-striatal RSFC of the topographically similar dorsal
                      caudate. We probed clinical relevance of the striatal
                      clusters by examining differences in their cortico-striatal
                      RSFC and gray matter (GM) volume between patients (with PD
                      and SCZ) and healthy controls. We found abnormal RSFC not
                      only between dorsal caudate, but also between rostral
                      caudate, ventral, central and caudal putamen and widespread
                      cortical regions for both PD and SCZ patients. Also, we
                      observed significant structural atrophy in rostral caudate,
                      ventral and central putamen for both PD and SCZ while
                      atrophy in the dorsal caudate was specific to PD. Taken
                      together, our cross-species comparative results revealed
                      shared and human-specific RSFC of different striatal
                      clusters reinforcing the complex organization and function
                      of the striatum. In addition, we provided a testable
                      hypothesis that abnormalities in a region with
                      human-specific connectivity, i.e., dorsal caudate, might be
                      associated with neuropsychiatric disorders.},
      cin          = {INM-7 / INM-11 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33819611},
      UT           = {WOS:000660300400008},
      doi          = {10.1016/j.neuroimage.2021.118006},
      url          = {https://juser.fz-juelich.de/record/891633},
}