% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{RivasAiello:891693,
      author       = {Rivas Aiello, María Belén and Azcárate, Julio C. and
                      Zelaya, Eugenia and David Gara, Pedro and Bosio, Gabriela N.
                      and Gensch, Thomas and Mártire, Daniel O.},
      title        = {{P}hotothermal therapy with silver nanoplates in {H}e{L}a
                      cells studied by in situ fluorescence microscopy},
      journal      = {Biomaterials science},
      volume       = {9},
      number       = {7},
      issn         = {2047-4849},
      address      = {Cambridge},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {FZJ-2021-01674},
      pages        = {2608 - 2619},
      year         = {2021},
      abstract     = {Photothermal therapy (PTT) is a noninvasive treatment for
                      cancer relying on the incorporation of NIR-light absorbing
                      nanomaterials into cells, which upon illumination release
                      heat causing thermally induced cell death. We prove that
                      irradiation of aqueous suspensions of
                      poly(vinylpyrrolidone)-coated silver nanoplates (PVPAgNP) or
                      PVPAgNP in HeLa cells with red or NIR lasers causes a
                      sizeable photothermal effect, which in cells can be
                      visualized with the temperature sensing fluorophore
                      Rhodamine B (RhB) using spinning disk confocal fluorescence
                      microscopy or fluorescence lifetime imaging. Upon red-light
                      irradiation of cells that were incubated with both, RhB and
                      PVPAgNP at concentrations with no adverse effects on cell
                      viability, a substantial heat release is detected.
                      Initiation of cell death by photothermal effect is observed
                      by positive signals of fluorescent markers for early and
                      late apoptosis. Surprisingly, a new nanomaterial-assisted
                      cell killing mode is operating when PVPAgNP-loaded HeLa
                      cells are excited with moderate powers of fs-pulsed NIR
                      light. Small roundish areas are generated with bright and
                      fast (<1 ns) decaying emission, which expand fast and
                      destroy the whole cell in seconds. This characteristic
                      emission is assigned to efficient optical breakdown
                      initiation around the strongly absorbing PVPAgNP leading to
                      plasma formation that spreads fast through the cell.},
      cin          = {IBI-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {524 - Molecular and Cellular Information Processing
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-524},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33595000},
      UT           = {WOS:000635690000001},
      doi          = {10.1039/D0BM01952F},
      url          = {https://juser.fz-juelich.de/record/891693},
}