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@ARTICLE{Lotter:891732,
      author       = {Lotter, Leon and von Polier, Georg and Offermann, Jan and
                      Buettgen, Kimberly and Stanetzky, Lukas and Eickhoff, Simon
                      B. and Konrad, Kerstin and Seitz, Jochen and Dukart,
                      Juergen},
      title        = {{R}ecovery-associated resting-state activity and
                      connectivity alterations in {A}norexia nervosa},
      journal      = {Biological psychiatry},
      volume       = {6},
      number       = {10},
      issn         = {2451-9022},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Inc.},
      reportid     = {FZJ-2021-01702},
      pages        = {1023-1033},
      year         = {2021},
      abstract     = {Background: Previous studies provided controversial insight
                      on the impact of starvation, disease status and underlying
                      grey matter volume (GMV) changes on resting-state functional
                      magnetic resonance imaging (rsfMRI) alterations in Anorexia
                      nervosa (AN). Here we adapt a combined longitudinal and
                      cross-sectional approach to disentangle the effects of these
                      factors on resting-state alterations in AN.Methods: Overall,
                      87 female subjects were included in the study: adolescent
                      patients with acute AN scanned at inpatient admission (N =
                      22, mean age 15.3 years) and at discharge (N = 21), 21
                      patients recovered from AN (22.3 years) and two groups of
                      healthy age-matched controls (both N = 22, 16.0 and 22.5
                      years). Whole-brain measures of resting-state activity and
                      functional connectivity were computed (Network Based
                      Statistics, Global Correlation, Integrated Local
                      Correlation, fractional Amplitude of Low Frequency
                      Fluctuations) to assess rsfMRI alterations over the course
                      of AN treatment before and after controlling for underlying
                      GMV.Results: Patients with acute AN displayed strong and
                      widespread prefrontal, sensorimotor, parietal, temporal,
                      precuneal and insular reductions of resting-state
                      connectivity and activity. All alterations were independent
                      of GMV and were largely normalized in short- and absent in
                      long-term recovered AN.Conclusions: Resting-state fMRI
                      alterations in AN constitute acute and GMV independent
                      presumably starvation-related phenomena. The majority of
                      alterations found here normalized over the course of
                      recovery without evidence for possible preexisting trait- or
                      remaining "scar"-effects.Keywords: Anorexia nervosa;
                      functional connectivity; grey matter volume; longitudinal;
                      recovery; resting-state functional magnetic resonance
                      imaging.},
      cin          = {INM-7 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-11-20170113},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / 89572 - (Dys-)function and Plasticity
                      (POF2-89572)},
      pid          = {G:(DE-HGF)POF4-525 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33766777},
      UT           = {WOS:000705934200012},
      doi          = {10.1016/j.bpsc.2021.03.006},
      url          = {https://juser.fz-juelich.de/record/891732},
}