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@ARTICLE{Grau:892055,
      author       = {Grau, S. and Herling, M. and Mauch, C. and Galldiks, N. and
                      Golla, H. and Schlamann, M. and Scheel, A. H. and Celik, E.
                      and Ruge, M. and Goldbrunner, R.},
      title        = {{H}irnmetastasen – interdisziplinär zu einer
                      personalisierten {B}ehandlung{B}rain
                      metastases–{I}nterdisciplinary approach towards a
                      personalized treatment},
      journal      = {Der Chirurg},
      volume       = {92},
      number       = {3},
      issn         = {1433-0385},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {FZJ-2021-01906},
      pages        = {200 - 209},
      year         = {2021},
      abstract     = {The incidence, treatment and prognosis of patients with
                      brain metastases have substantially changed during the last
                      decades. While the survival time after diagnosis of cerebral
                      metastases was on average a maximum of 3–6 months only 10
                      years ago, the survival time could be significantly improved
                      due to novel surgical, radiotherapeutic and systemic
                      treatment modalities. Only a few years ago, the occurrence
                      of brain metastases led to a withdrawal from systemic
                      oncological treatment and the exclusion of drug therapy
                      studies and to a purely palliatively oriented treatment in
                      the sense of whole brain radiation therapy (WBRT) with or
                      without surgery. The increasing availability of targeted and
                      immunomodulatory drugs as well as adapted radio-oncological
                      procedures enable increasingly more personalized treatment
                      approaches. The aim of this review article is to demonstrate
                      the progress and complexity of the treatment of brain
                      metastases in the context of modern comprehensive
                      interdisciplinary concepts.},
      cin          = {INM-3 / IEK-11 / IEK-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)IEK-11-20140314 /
                      I:(DE-Juel1)IEK-2-20101013},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33502584},
      UT           = {WOS:000612689200002},
      doi          = {10.1007/s00104-020-01344-y},
      url          = {https://juser.fz-juelich.de/record/892055},
}