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@ARTICLE{Murmiliuk:892333,
author = {Murmiliuk, Anastasiia and Filippov, Sergey K. and Rud, Oleg
and Košovan, Peter and Tošner, Zdeněk and Radulescu,
Aurel and Skandalis, Athanasios and Pispas, Stergios and
Šlouf, Miroslav and Štěpánek, Miroslav},
title = {{R}eversible multilayered vesicle-like structures with
fluid hydrophobic and interpolyelectrolyte layers},
journal = {Journal of colloid and interface science},
volume = {599},
issn = {0021-9797},
address = {Amsterdam [u.a.]},
publisher = {Elsevier},
reportid = {FZJ-2021-02004},
pages = {313 - 325},
year = {2021},
abstract = {Hydrophobic blocks of amphiphilic block copolymers often
form glassy micellar cores at room temperature with a rigid
structure that limits their applications as nanocapsules for
targeted delivery. Nevertheless, we prepared and analyzed
core/shell micelles with a soft core, formed by a
self-assembled block copolymer consisting of a hydrophobic
block and a polycation block, poly(lauryl
acrylate)-block-poly(trimethyl-aminoethyl acrylate)
(PLA-QPDMAEA), in aqueous solution. By light and small-angle
neutron scattering, by transmission electron microscopy and
by fluorescence spectroscopy, we showed that these
core/shell micelles are spherical and cylindrical with a
fluid-like PLA core and a positively charged outer shell and
that they can encapsulate and release hydrophobic solutes.
Moreover, after mixing these PLA-QPDMAEA core/shell micelles
with another diblock copolymer, consisting of a hydrophilic
block and a polyanion block, namely poly(ethylene
oxide)-block-poly(methacrylic acid) (PEO-PMAA), we observed
the formation of novel vesicle-like multicompartment
structures containing both soft hydrophobic and
interpolyelectrolyte (IPEC) layers. By combining small-angle
neutron scattering with self-consistent field modeling, we
confirmed the formation of these complex vesicle-like
structures with a swollen PEO core, an IPEC inner layer, a
PLA soft layer, an IPEC outer layer and a loose PEO corona.
Thus, these multicompartment micelles with fluid and IPEC
layers and a hydrophilic corona may be used as nanocapsules
with several tunable properties, including the ability to
control the thickness of each layer, the charge of the IPEC
layers and the stability of the micelles, to deliver both
hydrophobic and multivalent solutes.},
cin = {JCNS-FRM-II / MLZ / JCNS-4 / JCNS-1},
ddc = {540},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
I:(DE-Juel1)JCNS-4-20201012 / I:(DE-Juel1)JCNS-1-20110106},
pnm = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
(POF4-6G4) / 632 - Materials – Quantum, Complex and
Functional Materials (POF4-632)},
pid = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
experiment = {EXP:(DE-MLZ)KWS2-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {33957424},
UT = {WOS:000659386600005},
doi = {10.1016/j.jcis.2021.04.050},
url = {https://juser.fz-juelich.de/record/892333},
}