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@ARTICLE{Lothmann:892360,
author = {Lothmann, Kimberley and Amunts, Katrin and Herold,
Christina},
title = {{T}he {N}eurotransmitter {R}eceptor {A}rchitecture of the
{M}ouse {O}lfactory {S}ystem},
journal = {Frontiers in neuroanatomy},
volume = {15},
issn = {1662-5129},
address = {Lausanne},
publisher = {Frontiers Research Foundation},
reportid = {FZJ-2021-02021},
pages = {632549},
year = {2021},
abstract = {The uptake, transmission and processing of sensory
olfactory information is modulated by inhibitory and
excitatory receptors in the olfactory system. Previous
studies have focused on the function of individual receptors
in distinct brain areas, but the receptor architecture of
the whole system remains unclear. Here, we analyzed the
receptor profiles of the whole olfactory system of adult
male mice. We examined the distribution patterns of
glutamatergic (AMPA, kainate, mGlu2/3, and NMDA), GABAergic
(GABAA, GABAA(BZ), and GABAB), dopaminergic (D1/5) and
noradrenergic (α1 and α2) neurotransmitter receptors by
quantitative in vitro receptor autoradiography combined with
an analysis of the cyto- and myelo-architecture. We observed
that each subarea of the olfactory system is characterized
by individual densities of distinct neurotransmitter
receptor types, leading to a region- and layer-specific
receptor profile. Thereby, the investigated receptors in the
respective areas and strata showed a heterogeneous
expression. Generally, we detected high densities of
mGlu2/3Rs, GABAA(BZ)Rs and GABABRs. Noradrenergic receptors
revealed a highly heterogenic distribution, while the
dopaminergic receptor D1/5 displayed low concentrations,
except in the olfactory tubercle and the dorsal endopiriform
nucleus. The similarities and dissimilarities of the
area-specific multireceptor profiles were analyzed by a
hierarchical cluster analysis. A three-cluster solution was
found that divided the areas into the (1) olfactory relay
stations (main and accessory olfactory bulb), (2) the
olfactory cortex (anterior olfactory cortex, dorsal
peduncular cortex, taenia tecta, piriform cortex,
endopiriform nucleus, entorhinal cortex, orbitofrontal
cortex) and the (3) olfactory tubercle, constituting its own
cluster. The multimodal receptor-architectonic analysis of
each component of the olfactory system provides new insights
into its neurochemical organization and future possibilities
for pharmaceutic targeting},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {525 - Decoding Brain Organization and Dysfunction
(POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
Agreement 3 (945539)},
pid = {G:(DE-HGF)POF4-525 / G:(EU-Grant)945539},
typ = {PUB:(DE-HGF)16},
pubmed = {33967704},
UT = {WOS:000648100500001},
doi = {10.3389/fnana.2021.632549},
url = {https://juser.fz-juelich.de/record/892360},
}