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@ARTICLE{Lothmann:892360,
      author       = {Lothmann, Kimberley and Amunts, Katrin and Herold,
                      Christina},
      title        = {{T}he {N}eurotransmitter {R}eceptor {A}rchitecture of the
                      {M}ouse {O}lfactory {S}ystem},
      journal      = {Frontiers in neuroanatomy},
      volume       = {15},
      issn         = {1662-5129},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2021-02021},
      pages        = {632549},
      year         = {2021},
      abstract     = {The uptake, transmission and processing of sensory
                      olfactory information is modulated by inhibitory and
                      excitatory receptors in the olfactory system. Previous
                      studies have focused on the function of individual receptors
                      in distinct brain areas, but the receptor architecture of
                      the whole system remains unclear. Here, we analyzed the
                      receptor profiles of the whole olfactory system of adult
                      male mice. We examined the distribution patterns of
                      glutamatergic (AMPA, kainate, mGlu2/3, and NMDA), GABAergic
                      (GABAA, GABAA(BZ), and GABAB), dopaminergic (D1/5) and
                      noradrenergic (α1 and α2) neurotransmitter receptors by
                      quantitative in vitro receptor autoradiography combined with
                      an analysis of the cyto- and myelo-architecture. We observed
                      that each subarea of the olfactory system is characterized
                      by individual densities of distinct neurotransmitter
                      receptor types, leading to a region- and layer-specific
                      receptor profile. Thereby, the investigated receptors in the
                      respective areas and strata showed a heterogeneous
                      expression. Generally, we detected high densities of
                      mGlu2/3Rs, GABAA(BZ)Rs and GABABRs. Noradrenergic receptors
                      revealed a highly heterogenic distribution, while the
                      dopaminergic receptor D1/5 displayed low concentrations,
                      except in the olfactory tubercle and the dorsal endopiriform
                      nucleus. The similarities and dissimilarities of the
                      area-specific multireceptor profiles were analyzed by a
                      hierarchical cluster analysis. A three-cluster solution was
                      found that divided the areas into the (1) olfactory relay
                      stations (main and accessory olfactory bulb), (2) the
                      olfactory cortex (anterior olfactory cortex, dorsal
                      peduncular cortex, taenia tecta, piriform cortex,
                      endopiriform nucleus, entorhinal cortex, orbitofrontal
                      cortex) and the (3) olfactory tubercle, constituting its own
                      cluster. The multimodal receptor-architectonic analysis of
                      each component of the olfactory system provides new insights
                      into its neurochemical organization and future possibilities
                      for pharmaceutic targeting},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-525 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33967704},
      UT           = {WOS:000648100500001},
      doi          = {10.3389/fnana.2021.632549},
      url          = {https://juser.fz-juelich.de/record/892360},
}