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000892363 0247_ $$2doi$$a10.1093/cercor/bhab073
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000892363 1001_ $$0P:(DE-HGF)0$$aPérez-Santos, I.$$b0
000892363 245__ $$aDistribution of the noradrenaline innervation and adrenoceptors in the macaque monkey thalamus
000892363 260__ $$aOxford$$bOxford Univ. Press$$c2021
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000892363 520__ $$aNoradrenaline (NA) in the thalamus has important roles in physiological, pharmacological, and pathological neuromodulation. In this work, a complete characterization of NA axons and Alpha adrenoceptors distributions is provided.NA axons, revealed by immunohistochemistry against the synthesizing enzyme and the NA transporter, are present in all thalamic nuclei. The most densely innervated ones are the midline nuclei, intralaminar nuclei (paracentral and parafascicular), and the medial sector of the mediodorsal nucleus (MDm). The ventral motor nuclei and most somatosensory relay nuclei receive a moderate NA innervation. The pulvinar complex receives a heterogeneous innervation. The lateral geniculate nucleus (GL) has the lowest NA innervation.Alpha adrenoceptors were analyzed by in vitro quantitative autoradiography. Alpha-1 receptor densities are higher than Alpha-2 densities. Overall, axonal densities and Alpha adrenoceptor densities coincide; although some mismatches were identified. The nuclei with the highest Alpha-1 values are MDm, the parvocellular part of the ventral posterior medial nucleus, medial pulvinar, and midline nuclei. The nucleus with the lowest Alpha-1 receptor density is GL. Alpha-2 receptor densities are highest in the lateral dorsal, centromedian, medial and inferior pulvinar, and midline nuclei.These results suggest a role for NA in modulating thalamic involvement in consciousness, limbic, cognitive, and executive functions.
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000892363 536__ $$0G:(EU-Grant)785907$$aHBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907)$$c785907$$fH2020-SGA-FETFLAG-HBP-2017$$x2
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000892363 7001_ $$0P:(DE-Juel1)131701$$aPalomero-Gallagher, Nicola$$b1$$eCorresponding author
000892363 7001_ $$0P:(DE-Juel1)131714$$aZilles, Karl$$b2
000892363 7001_ $$0P:(DE-HGF)0$$aCavada, C.$$b3$$eCorresponding author
000892363 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhab073$$n9$$p4115–4139$$tCerebral cortex$$v31$$x1047-3211$$y2021
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