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@ARTICLE{PrezSantos:892363,
      author       = {Pérez-Santos, I. and Palomero-Gallagher, Nicola and
                      Zilles, Karl and Cavada, C.},
      title        = {{D}istribution of the noradrenaline innervation and
                      adrenoceptors in the macaque monkey thalamus},
      journal      = {Cerebral cortex},
      volume       = {31},
      number       = {9},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2021-02024},
      pages        = {4115–4139},
      year         = {2021},
      abstract     = {Noradrenaline (NA) in the thalamus has important roles in
                      physiological, pharmacological, and pathological
                      neuromodulation. In this work, a complete characterization
                      of NA axons and Alpha adrenoceptors distributions is
                      provided.NA axons, revealed by immunohistochemistry against
                      the synthesizing enzyme and the NA transporter, are present
                      in all thalamic nuclei. The most densely innervated ones are
                      the midline nuclei, intralaminar nuclei (paracentral and
                      parafascicular), and the medial sector of the mediodorsal
                      nucleus (MDm). The ventral motor nuclei and most
                      somatosensory relay nuclei receive a moderate NA
                      innervation. The pulvinar complex receives a heterogeneous
                      innervation. The lateral geniculate nucleus (GL) has the
                      lowest NA innervation.Alpha adrenoceptors were analyzed by
                      in vitro quantitative autoradiography. Alpha-1 receptor
                      densities are higher than Alpha-2 densities. Overall, axonal
                      densities and Alpha adrenoceptor densities coincide;
                      although some mismatches were identified. The nuclei with
                      the highest Alpha-1 values are MDm, the parvocellular part
                      of the ventral posterior medial nucleus, medial pulvinar,
                      and midline nuclei. The nucleus with the lowest Alpha-1
                      receptor density is GL. Alpha-2 receptor densities are
                      highest in the lateral dorsal, centromedian, medial and
                      inferior pulvinar, and midline nuclei.These results suggest
                      a role for NA in modulating thalamic involvement in
                      consciousness, limbic, cognitive, and executive functions.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539) / HBP SGA2 - Human Brain Project
                      Specific Grant Agreement 2 (785907) / 3D-MMA -
                      3D-MMA-Gradienten der Verteilung multipler
                      Transmitterrezeptoren in der Hirnrinde als Grundlage
                      verteilter kognitiver, sensorischer und motorischer
                      Funktionen (BMBF-01GQ1902)},
      pid          = {G:(DE-HGF)POF4-525 / G:(EU-Grant)945539 /
                      G:(EU-Grant)785907 / G:(DE-Juel-1)BMBF-01GQ1902},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34003210},
      UT           = {WOS:000741349100011},
      doi          = {10.1093/cercor/bhab073},
      url          = {https://juser.fz-juelich.de/record/892363},
}