Home > Publications database > Distribution of the noradrenaline innervation and adrenoceptors in the macaque monkey thalamus > print

001     892363
005     20220126162542.0
024 7 _ |a 10.1093/cercor/bhab073
|2 doi
024 7 _ |a 2128/28416
|2 Handle
024 7 _ |a 34003210
|2 pmid
024 7 _ |a WOS:000741349100011
|2 WOS
037 _ _ |a FZJ-2021-02024
082 _ _ |a 610
100 1 _ |a Pérez-Santos, I.
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Distribution of the noradrenaline innervation and adrenoceptors in the macaque monkey thalamus
260 _ _ |a Oxford
|c 2021
|b Oxford Univ. Press
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1628149748_17105
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Noradrenaline (NA) in the thalamus has important roles in physiological, pharmacological, and pathological neuromodulation. In this work, a complete characterization of NA axons and Alpha adrenoceptors distributions is provided.NA axons, revealed by immunohistochemistry against the synthesizing enzyme and the NA transporter, are present in all thalamic nuclei. The most densely innervated ones are the midline nuclei, intralaminar nuclei (paracentral and parafascicular), and the medial sector of the mediodorsal nucleus (MDm). The ventral motor nuclei and most somatosensory relay nuclei receive a moderate NA innervation. The pulvinar complex receives a heterogeneous innervation. The lateral geniculate nucleus (GL) has the lowest NA innervation.Alpha adrenoceptors were analyzed by in vitro quantitative autoradiography. Alpha-1 receptor densities are higher than Alpha-2 densities. Overall, axonal densities and Alpha adrenoceptor densities coincide; although some mismatches were identified. The nuclei with the highest Alpha-1 values are MDm, the parvocellular part of the ventral posterior medial nucleus, medial pulvinar, and midline nuclei. The nucleus with the lowest Alpha-1 receptor density is GL. Alpha-2 receptor densities are highest in the lateral dorsal, centromedian, medial and inferior pulvinar, and midline nuclei.These results suggest a role for NA in modulating thalamic involvement in consciousness, limbic, cognitive, and executive functions.
536 _ _ |a 525 - Decoding Brain Organization and Dysfunction (POF4-525)
|0 G:(DE-HGF)POF4-525
|c POF4-525
|f POF IV
|x 0
536 _ _ |a HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)
|0 G:(EU-Grant)945539
|c 945539
|x 1
536 _ _ |a HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907)
|0 G:(EU-Grant)785907
|c 785907
|f H2020-SGA-FETFLAG-HBP-2017
|x 2
536 _ _ |a 3D-MMA - 3D-MMA-Gradienten der Verteilung multipler Transmitterrezeptoren in der Hirnrinde als Grundlage verteilter kognitiver, sensorischer und motorischer Funktionen (BMBF-01GQ1902)
|0 G:(DE-Juel-1)BMBF-01GQ1902
|c BMBF-01GQ1902
|x 3
700 1 _ |a Palomero-Gallagher, Nicola
|0 P:(DE-Juel1)131701
|b 1
|e Corresponding author
700 1 _ |a Zilles, Karl
|0 P:(DE-Juel1)131714
|b 2
700 1 _ |a Cavada, C.
|0 P:(DE-HGF)0
|b 3
|e Corresponding author
773 _ _ |a 10.1093/cercor/bhab073
|0 PERI:(DE-600)1483485-6
|n 9
|p 4115–4139
|t Cerebral cortex
|v 31
|y 2021
|x 1047-3211
856 4 _ |u https://juser.fz-juelich.de/record/892363/files/bhab073.pdf
|y OpenAccess
909 C O |o oai:juser.fz-juelich.de:892363
|p openaire
|p open_access
|p driver
|p VDB
|p ec_fundedresources
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 1
|6 P:(DE-Juel1)131701
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)131714
913 1 _ |a DE-HGF
|b Key Technologies
|l Natural, Artificial and Cognitive Information Processing
|1 G:(DE-HGF)POF4-520
|0 G:(DE-HGF)POF4-525
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-500
|4 G:(DE-HGF)POF
|v Decoding Brain Organization and Dysfunction
|x 0
913 0 _ |a DE-HGF
|b Key Technologies
|l Decoding the Human Brain
|1 G:(DE-HGF)POF3-570
|0 G:(DE-HGF)POF3-571
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-500
|4 G:(DE-HGF)POF
|v Connectivity and Activity
|x 0
914 1 _ |y 2021
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-01-26
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CEREB CORTEX : 2019
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2021-01-26
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2021-01-26
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b CEREB CORTEX : 2019
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
|d 2021-01-26
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2021-01-26
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2021-01-26
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)INM-1-20090406
|k INM-1
|l Strukturelle und funktionelle Organisation des Gehirns
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)INM-1-20090406
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21