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@ARTICLE{Kocher:892559,
      author       = {Kocher, Martin and Jockwitz, Christiane and Lohmann,
                      Philipp and Stoffels, Gabriele and Filss, Christian and
                      Mottaghy, Felix M. and Ruge, Maximilian I. and Weiss Lucas,
                      Carolin and Goldbrunner, Roland and Shah, N. J. and Fink,
                      Gereon R. and Galldiks, Norbert and Langen, Karl-Josef and
                      Caspers, Svenja},
      title        = {{L}esion-{F}unction {A}nalysis from {M}ultimodal {I}maging
                      and {N}ormative {B}rain {A}tlases for {P}rediction of
                      {C}ognitive {D}eficits in {G}lioma {P}atients},
      journal      = {Cancers},
      volume       = {13},
      number       = {10},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-02158},
      pages        = {2373 -},
      year         = {2021},
      abstract     = {Cognitive deficits are common in glioma patients following
                      multimodality therapy, but the relative impact of different
                      types and locations of treatment-related brain damage and
                      recurrent tumors on cognition is not well understood. In 121
                      WHO Grade III/IV glioma patients, structural MRI,
                      O-(2-[18F]fluoroethyl)-L-tyrosine FET-PET, and
                      neuropsychological testing were performed at a median
                      interval of 14 months (range, 1–214 months) after therapy
                      initiation. Resection cavities, T1-enhancing lesions,
                      T2/FLAIR hyperintensities, and FET-PET positive tumor sites
                      were semi-automatically segmented and elastically registered
                      to a normative, resting state (RS) fMRI-based functional
                      cortical network atlas and to the JHU atlas of white matter
                      (WM) tracts, and their influence on cognitive test scores
                      relative to a cohort of matched healthy subjects was
                      assessed. T2/FLAIR hyperintensities presumably caused by
                      radiation therapy covered more extensive brain areas than
                      the other lesion types and significantly impaired cognitive
                      performance in many domains when affecting left-hemispheric
                      RS-nodes and WM-tracts as opposed to brain tissue damage
                      caused by resection or recurrent tumors. Verbal episodic
                      memory proved to be especially vulnerable to T2/FLAIR
                      abnormalities affecting the nodes and tracts of the left
                      temporal lobe. In order to improve radiotherapy planning,
                      publicly available brain atlases, in conjunction with
                      elastic registration techniques, should be used, similar to
                      neuronavigation in neurosurgery.},
      cin          = {INM-4 / INM-11 / INM-1 / INM-3 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)VDB1046},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-525 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34069074},
      UT           = {WOS:000654648600001},
      doi          = {10.3390/cancers13102373},
      url          = {https://juser.fz-juelich.de/record/892559},
}