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@INPROCEEDINGS{Lee:892582,
      author       = {Lee, Namkyu and Wiegand, Simone},
      title        = {{D}evelopment of thermophoretic µ-device for measuring
                      {S}oret coefficient},
      reportid     = {FZJ-2021-02179},
      year         = {2021},
      abstract     = {Thermophoresis is the mass transport induced by a
                      temperature gradient where the Soret coefficient ST is a
                      measure for the established concentration gradient in a
                      temperature gradient. It has gained a lot of interest in the
                      biotechnology to monitor the binding between proteins and
                      ligands [1]. To obtain quantitative thermophoretic
                      parameters in those complex systems, the existing methods
                      are not suitable as they are limited to binary mixtures or
                      consume large sample amounts in the order of 30-50 mL.
                      Recently, a thermophoretic lab-on-a-chip device with a small
                      sample volume of 10 µL was developed to measure ST using a
                      confocal microscope. With a microwire for heating, large
                      temperature gradients up to ~106 K/m could be achieved [2].
                      However, a 3D temperature profile around the wire
                      complicated the analysis for determining ST. To overcome the
                      drawback of this chip, we propose a thermophoretic µ-device
                      with a 1D temperature profile. In this instrument a
                      measurement channel with a sample volume of 20 µL lies
                      between a heating and cooling channel. Temperature gradients
                      up to ~104 K/m can be achieved. Using a confocal microscope,
                      the temperature profile is measured by fluorescence lifetime
                      imaging microscopy (FLIM) with Rhodamine B (RhB) and the
                      concentration is determined from the fluorescence intensity.
                      Fluorescent polystyrene particles with a diameter of 25 nm
                      are used for comparing ST to a validated optical method
                      (Thermal Diffusion Forced Rayleigh Scattering (TDFRS)) [3]
                      and the recently developed thermophoretic chip [2]. ST
                      probed by the developed device agrees within the uncertainty
                      with TDFRS and thermophoretic lab-on-a-chip
                      measurements.Literature:[1] D. Niether and S. Wiegand, J.
                      Phys. Condens. Matter 31, 2019, 503003. [2] N. Lee, D.
                      Afanasenkau, P. Rinklin, B. Wolfrum, and S. Wiegand, Lab
                      Chip, Submitted[3] O. Syshchyk, et al., Eur. Phys. J. E,
                      2016, 39, 129},
      month         = {May},
      date          = {2021-05-10},
      organization  = {Bunsen-Tagung 2021 - Multi-Scale
                       Modelling $\&$ Physical Chemistry of
                       Colloids, Virtual (Germany), 10 May
                       2021 - 12 May 2021},
      subtyp        = {Other},
      cin          = {IBI-4},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {524 - Molecular and Cellular Information Processing
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-524},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/892582},
}