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000892593 1001_ $$00000-0002-4546-017X$$aMooney, Brian C$$b0
000892593 245__ $$aCutting the line: manipulation of plant immunity by bacterial type III effector proteases
000892593 260__ $$aOxford$$bOxford Univ. Press$$c2021
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000892593 520__ $$aPathogens and their hosts are engaged in an evolutionary arms race. Pathogen-derived effectors promote virulence by targeting components of a host’s innate immune system, while hosts have evolved proteins that sense effectors and trigger a pathogen-specific immune response. Many bacterial effectors are translocated into host cells using type III secretion systems. Type III effector proteases irreversibly modify host proteins by cleavage of peptide bonds and are prevalent among both plant and animal bacterial pathogens. In plants, the study of model effector proteases has yielded important insights into the virulence mechanisms employed by pathogens to overcome their host’s immune response, as well as into the mechanisms deployed by their hosts to detect these effector proteases and counteract their effects. In recent years, the study of a larger number of effector proteases, across a wider range of pathogens, has yielded novel insights into their functions and recognition. One key limitation that remains is the lack of methods to detect protease cleavage at the proteome-wide level. We review known substrates and mechanisms of plant pathogen type III effector proteases and compare their functions with those of known type III effector proteases of mammalian pathogens. Finally, we discuss approaches to uncover their function on a system-wide level.
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000892593 536__ $$0G:(EU-Grant)639905$$aProPlantStress - Proteolytic processing in plant stress signal transduction and responses to abiotic stress and pathogen attack (639905)$$c639905$$fERC-2014-STG$$x1
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000892593 7001_ $$0P:(DE-Juel1)184834$$aMantz, Melissa$$b1$$ufzj
000892593 7001_ $$00000-0003-3548-8213$$aGraciet, Emmanuelle$$b2$$eCorresponding author
000892593 7001_ $$0P:(DE-Juel1)162356$$aHuesgen, Pitter F$$b3$$eCorresponding author
000892593 773__ $$0PERI:(DE-600)1466717-4$$a10.1093/jxb/erab095$$gVol. 72, no. 9, p. 3395 - 3409$$n9$$p3395 - 3409$$tThe journal of experimental botany$$v72$$x1460-2431$$y2021
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000892593 8564_ $$uhttps://juser.fz-juelich.de/record/892593/files/Mooney_et_al_revised%20manuscript_references_edited.pdf$$yPublished on 2021-02-26. Available in OpenAccess from 2022-02-26.
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