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@ARTICLE{Mooney:892593,
      author       = {Mooney, Brian C and Mantz, Melissa and Graciet, Emmanuelle
                      and Huesgen, Pitter F},
      title        = {{C}utting the line: manipulation of plant immunity by
                      bacterial type {III} effector proteases},
      journal      = {The journal of experimental botany},
      volume       = {72},
      number       = {9},
      issn         = {1460-2431},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2021-02183},
      pages        = {3395 - 3409},
      year         = {2021},
      abstract     = {Pathogens and their hosts are engaged in an evolutionary
                      arms race. Pathogen-derived effectors promote virulence by
                      targeting components of a host’s innate immune system,
                      while hosts have evolved proteins that sense effectors and
                      trigger a pathogen-specific immune response. Many bacterial
                      effectors are translocated into host cells using type III
                      secretion systems. Type III effector proteases irreversibly
                      modify host proteins by cleavage of peptide bonds and are
                      prevalent among both plant and animal bacterial pathogens.
                      In plants, the study of model effector proteases has yielded
                      important insights into the virulence mechanisms employed by
                      pathogens to overcome their host’s immune response, as
                      well as into the mechanisms deployed by their hosts to
                      detect these effector proteases and counteract their
                      effects. In recent years, the study of a larger number of
                      effector proteases, across a wider range of pathogens, has
                      yielded novel insights into their functions and recognition.
                      One key limitation that remains is the lack of methods to
                      detect protease cleavage at the proteome-wide level. We
                      review known substrates and mechanisms of plant pathogen
                      type III effector proteases and compare their functions with
                      those of known type III effector proteases of mammalian
                      pathogens. Finally, we discuss approaches to uncover their
                      function on a system-wide level.},
      cin          = {ZEA-3},
      ddc          = {580},
      cid          = {I:(DE-Juel1)ZEA-3-20090406},
      pnm          = {217 - Für eine nachhaltige Bio-Ökonomie – von
                      Ressourcen zu Produkten (POF4-217) / ProPlantStress -
                      Proteolytic processing in plant stress signal transduction
                      and responses to abiotic stress and pathogen attack
                      (639905)},
      pid          = {G:(DE-HGF)POF4-217 / G:(EU-Grant)639905},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33640987},
      UT           = {WOS:000707097500006},
      doi          = {10.1093/jxb/erab095},
      url          = {https://juser.fz-juelich.de/record/892593},
}