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@ARTICLE{Demir:892594,
      author       = {Demir, Fatih and Troldborg, Anne and Thiel, Steffen and
                      Lassé, Moritz and Huesgen, Pitter and Tomas, Nicola M. and
                      Wiech, Thorsten and Rinschen, Markus M.},
      title        = {{P}roteolysis and inflammation of the kidney glomerulus},
      journal      = {Cell $\&$ tissue research},
      volume       = {385},
      issn         = {1432-0878},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2021-02184},
      pages        = {489–500},
      year         = {2021},
      abstract     = {Proteases play a central role in regulating renal
                      pathophysiology and are increasingly evaluated as actionable
                      drug targets. Here, we review the role of proteolytic
                      systems in inflammatory kidney disease. Inflammatory kidney
                      diseases are associated with broad dysregulations of
                      extracellular and intracellular proteolysis. As an example
                      of a proteolytic system, the complement system plays a
                      significant role in glomerular inflammatory kidney disease
                      and is currently under clinical investigation. Based on two
                      glomerular kidney diseases, lupus nephritis, and membranous
                      nephropathy, we portrait two proteolytic pathomechanisms and
                      the role of the complement system. We discuss how profiling
                      proteolytic activity in patient samples could be used to
                      stratify patients for more targeted interventions in
                      inflammatory kidney diseases. We also describe novel
                      comprehensive, quantitative tools to investigate the
                      entirety of proteolytic processes in a tissue sample.
                      Emphasis is placed on mass spectrometric approaches that
                      enable the comprehensive analysis of the complement system,
                      as well as protease activities and regulation in general.},
      cin          = {ZEA-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ZEA-3-20090406},
      pnm          = {524 - Molecular and Cellular Information Processing
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-524},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33864499},
      UT           = {WOS:000640856700003},
      doi          = {10.1007/s00441-021-03433-8},
      url          = {https://juser.fz-juelich.de/record/892594},
}