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@ARTICLE{Wu:892629,
      author       = {Wu, Shuyi and Sun, Sai and Camilleri, Julia and Eickhoff,
                      Simon B. and Yu, Rongjun},
      title        = {{B}etter the devil you know than the devil you don't:
                      {N}eural processing of risk and ambiguity},
      journal      = {NeuroImage},
      volume       = {236},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2021-02218},
      pages        = {118109 -},
      year         = {2021},
      abstract     = {Risk and ambiguity are inherent in virtually all human
                      decision-making. Risk refers to a situation in which we know
                      the precise probability of potential outcomes of each
                      option, whereas ambiguity refers to a situation in which
                      outcome probabilities are not known. A large body of
                      research has shown that individuals prefer known risks to
                      ambiguity, a phenomenon known as ambiguity aversion. One
                      heated debate concerns whether risky and ambiguous decisions
                      rely on the same or distinct neural circuits. In the current
                      meta-analyses, we integrated the results of neuroimaging
                      research on decision-making under risk (n = 69) and
                      ambiguity (n = 31). Our results showed that both processing
                      of risk and ambiguity showed convergence in anterior insula,
                      indicating a key role of anterior insula in encoding
                      uncertainty. Risk additionally engaged dorsomedial
                      prefrontal cortex (dmPFC) and ventral striatum, whereas
                      ambiguity specifically recruited the dorsolateral prefrontal
                      cortex (dlPFC), inferior parietal lobe (IPL) and right
                      anterior insula. Our findings demonstrate overlapping and
                      distinct neural substrates underlying different types of
                      uncertainty, guiding future neuroimaging research on
                      risk-taking and ambiguity aversion.Keywords: ALE; Ambiguity;
                      Meta-analysis; Neuroimaging; Reward; Risk; Uncertainty.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33940147},
      UT           = {WOS:000668960100005},
      doi          = {10.1016/j.neuroimage.2021.118109},
      url          = {https://juser.fz-juelich.de/record/892629},
}