000892757 001__ 892757
000892757 005__ 20211130111105.0
000892757 0247_ $$2doi$$a10.1007/s00234-021-02731-w
000892757 0247_ $$2ISSN$$a0028-3940
000892757 0247_ $$2ISSN$$a1432-1920
000892757 0247_ $$2Handle$$a2128/29064
000892757 0247_ $$2altmetric$$aaltmetric:106241436
000892757 0247_ $$2pmid$$apmid:34019112
000892757 0247_ $$2WOS$$aWOS:000652934600003
000892757 037__ $$aFZJ-2021-02314
000892757 082__ $$a610
000892757 1001_ $$0P:(DE-Juel1)144344$$aCaspers, Julian$$b0
000892757 245__ $$aWithin- and across-network alterations of the sensorimotor network in Parkinson’s disease
000892757 260__ $$aHeidelberg$$bSpringer$$c2021
000892757 3367_ $$2DRIVER$$aarticle
000892757 3367_ $$2DataCite$$aOutput Types/Journal article
000892757 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1637322905_22820
000892757 3367_ $$2BibTeX$$aARTICLE
000892757 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000892757 3367_ $$00$$2EndNote$$aJournal Article
000892757 520__ $$aPurpose: Parkinson's disease (PD) is primarily defined by motor symptoms and is associated with alterations of sensorimotor areas. Evidence for network changes of the sensorimotor network (SMN) in PD is inconsistent and a systematic evaluation of SMN in PD yet missing. We investigate functional connectivity changes of the SMN in PD, both, within the network, and to other large-scale connectivity networks.Methods: Resting-state fMRI was assessed in 38 PD patients under long-term dopaminergic treatment and 43 matched healthy controls (HC). Independent component analysis (ICA) into 20 components was conducted and the SMN was identified within the resulting networks. Functional connectivity within the SMN was analyzed using a dual regression approach. Connectivity between the SMN and the other networks from group ICA was investigated with FSLNets. We investigated for functional connectivity changes between patients and controls as well as between medication states (OFF vs. ON) in PD and for correlations with clinical parameters.Results: There was decreased functional connectivity within the SMN in left inferior parietal and primary somatosensory cortex in PD OFF. Across networks, connectivity between SMN and two motor networks as well as two visual networks was diminished in PD OFF. All connectivity decreases partially normalized in PD ON.Conclusion: PD is accompanied by functional connectivity losses of the SMN, both, within the network and in interaction to other networks. The connectivity changes in short- and long-range connections are probably related to impaired sensory integration for motor function in PD. SMN decoupling can be partially compensated by dopaminergic therapy.
000892757 536__ $$0G:(DE-HGF)POF4-525$$a525 - Decoding Brain Organization and Dysfunction (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000892757 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000892757 7001_ $$0P:(DE-HGF)0$$aRubbert, Christian$$b1$$eCorresponding author
000892757 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b2
000892757 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b3
000892757 7001_ $$0P:(DE-HGF)0$$aSüdmeyer, Martin$$b4
000892757 7001_ $$0P:(DE-HGF)0$$aHartmann, Christian J.$$b5
000892757 7001_ $$0P:(DE-Juel1)171897$$aSigl, Benjamin$$b6
000892757 7001_ $$0P:(DE-HGF)0$$aTeichert, Nikolas$$b7
000892757 7001_ $$0P:(DE-HGF)0$$aAissa, Joel$$b8
000892757 7001_ $$0P:(DE-HGF)0$$aTurowski, Bernd$$b9
000892757 7001_ $$00000-0002-6414-7939$$aSchnitzler, Alfons$$b10
000892757 7001_ $$0P:(DE-HGF)0$$aMathys, Christian$$b11
000892757 773__ $$0PERI:(DE-600)1462953-7$$a10.1007/s00234-021-02731-w$$p2073–2085 $$tNeuroradiology$$v63$$x0028-3940$$y2021
000892757 8564_ $$uhttps://juser.fz-juelich.de/record/892757/files/Caspers2021_Article_Within-AndAcross-networkAltera.pdf$$yOpenAccess
000892757 909CO $$ooai:juser.fz-juelich.de:892757$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000892757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b2$$kFZJ
000892757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131684$$aForschungszentrum Jülich$$b3$$kFZJ
000892757 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000892757 9130_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000892757 9141_ $$y2021
000892757 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-02
000892757 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000892757 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEURORADIOLOGY : 2019$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2021-02-02$$wger
000892757 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000892757 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-02-02
000892757 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-02-02$$wger
000892757 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-02
000892757 920__ $$lyes
000892757 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000892757 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x1
000892757 980__ $$ajournal
000892757 980__ $$aVDB
000892757 980__ $$aUNRESTRICTED
000892757 980__ $$aI:(DE-Juel1)INM-7-20090406
000892757 980__ $$aI:(DE-Juel1)INM-1-20090406
000892757 9801_ $$aFullTexts