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@ARTICLE{Caspers:892757,
      author       = {Caspers, Julian and Rubbert, Christian and Eickhoff, Simon
                      B. and Hoffstaedter, Felix and Südmeyer, Martin and
                      Hartmann, Christian J. and Sigl, Benjamin and Teichert,
                      Nikolas and Aissa, Joel and Turowski, Bernd and Schnitzler,
                      Alfons and Mathys, Christian},
      title        = {{W}ithin- and across-network alterations of the
                      sensorimotor network in {P}arkinson’s disease},
      journal      = {Neuroradiology},
      volume       = {63},
      issn         = {0028-3940},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2021-02314},
      pages        = {2073–2085},
      year         = {2021},
      abstract     = {Purpose: Parkinson's disease (PD) is primarily defined by
                      motor symptoms and is associated with alterations of
                      sensorimotor areas. Evidence for network changes of the
                      sensorimotor network (SMN) in PD is inconsistent and a
                      systematic evaluation of SMN in PD yet missing. We
                      investigate functional connectivity changes of the SMN in
                      PD, both, within the network, and to other large-scale
                      connectivity networks.Methods: Resting-state fMRI was
                      assessed in 38 PD patients under long-term dopaminergic
                      treatment and 43 matched healthy controls (HC). Independent
                      component analysis (ICA) into 20 components was conducted
                      and the SMN was identified within the resulting networks.
                      Functional connectivity within the SMN was analyzed using a
                      dual regression approach. Connectivity between the SMN and
                      the other networks from group ICA was investigated with
                      FSLNets. We investigated for functional connectivity changes
                      between patients and controls as well as between medication
                      states (OFF vs. ON) in PD and for correlations with clinical
                      parameters.Results: There was decreased functional
                      connectivity within the SMN in left inferior parietal and
                      primary somatosensory cortex in PD OFF. Across networks,
                      connectivity between SMN and two motor networks as well as
                      two visual networks was diminished in PD OFF. All
                      connectivity decreases partially normalized in PD
                      ON.Conclusion: PD is accompanied by functional connectivity
                      losses of the SMN, both, within the network and in
                      interaction to other networks. The connectivity changes in
                      short- and long-range connections are probably related to
                      impaired sensory integration for motor function in PD. SMN
                      decoupling can be partially compensated by dopaminergic
                      therapy.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34019112},
      UT           = {WOS:000652934600003},
      doi          = {10.1007/s00234-021-02731-w},
      url          = {https://juser.fz-juelich.de/record/892757},
}