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000892758 0247_ $$2doi$$a10.1093/alcalc/agab026
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000892758 1001_ $$0P:(DE-HGF)0$$aFurtmann, Johanna K$$b0$$eCorresponding author
000892758 245__ $$aMRI Analysis Of the Water Content Change In the Brain During Acute Ethanol Consumption Via Quantitative Water Mapping
000892758 260__ $$aOxford$$bOxford Univ. Press$$c2022
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000892758 520__ $$aAimsAlcohol consumption influences the water balance in the brain. While the impact of chronic alcohol misuse on cerebral water content has been the subject of several studies, less is known about the effects of acute alcohol misuse, with contradictory results in the literature. Therefore, we investigated the effects of acute alcohol intoxication on cerebral water content using a precise quantitative magnetic resonance imaging (MRI) sequence.MethodsIn a prospective study, we measured cerebral water content in 20 healthy volunteers before alcohol consumption and after reaching a breath alcohol concentration of 1 ‰. A quantitative MRI water mapping sequence was conducted on a clinical 3 T system. Non-alcoholic fluid input and output were documented and accounted for. Water content was assessed for whole brain, grey and white matter and more specifically for regions known to be affected by acute or chronic alcohol misuse (occipital and frontal lobes, thalamus and pons). Changes in the volume of grey and white matter as well as the whole brain were examined.ResultsQuantitative cerebral water content before and after acute alcohol consumption did not differ significantly (P ≥ 0.07), with changes often being within the range of measurement accuracy. Whole brain, white and grey matter volume did not change significantly (P ≥ 0.12).ConclusionThe results of our study show no significant water content or volume change in the brain after recent alcohol intake in healthy volunteers. This accounts for the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons.
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000892758 7001_ $$0P:(DE-HGF)0$$aSichtermann, Thorsten$$b1
000892758 7001_ $$0P:(DE-Juel1)131782$$aOros-Peusquens, Ana-Maria$$b2$$ufzj
000892758 7001_ $$0P:(DE-HGF)0$$aDekeyzer, Sven$$b3
000892758 7001_ $$0P:(DE-Juel1)131794$$aShah, Nadim J$$b4$$ufzj
000892758 7001_ $$0P:(DE-HGF)0$$aWiesmann, Martin$$b5
000892758 7001_ $$0P:(DE-Juel1)162385$$aNikoubashman, Omid$$b6
000892758 773__ $$0PERI:(DE-600)1483492-3$$a10.1093/alcalc/agab026$$gp. agab026$$n4$$p429–436$$tAlcohol and alcoholism$$v57$$x0735-0414$$y2022
000892758 8564_ $$uhttps://juser.fz-juelich.de/record/892758/files/2021_Furtmann_AlcoholandAlcoholism_Postprint.pdf$$yPublished on 2021-05-18. Available in OpenAccess from 2022-05-18.
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