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@ARTICLE{Furtmann:892758,
      author       = {Furtmann, Johanna K and Sichtermann, Thorsten and
                      Oros-Peusquens, Ana-Maria and Dekeyzer, Sven and Shah, Nadim
                      J and Wiesmann, Martin and Nikoubashman, Omid},
      title        = {{MRI} {A}nalysis {O}f the {W}ater {C}ontent {C}hange {I}n
                      the {B}rain {D}uring {A}cute {E}thanol {C}onsumption {V}ia
                      {Q}uantitative {W}ater {M}apping},
      journal      = {Alcohol and alcoholism},
      volume       = {57},
      number       = {4},
      issn         = {0735-0414},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2021-02315},
      pages        = {429–436},
      year         = {2022},
      abstract     = {AimsAlcohol consumption influences the water balance in the
                      brain. While the impact of chronic alcohol misuse on
                      cerebral water content has been the subject of several
                      studies, less is known about the effects of acute alcohol
                      misuse, with contradictory results in the literature.
                      Therefore, we investigated the effects of acute alcohol
                      intoxication on cerebral water content using a precise
                      quantitative magnetic resonance imaging (MRI)
                      sequence.MethodsIn a prospective study, we measured cerebral
                      water content in 20 healthy volunteers before alcohol
                      consumption and after reaching a breath alcohol
                      concentration of 1 ‰. A quantitative MRI water mapping
                      sequence was conducted on a clinical 3 T system.
                      Non-alcoholic fluid input and output were documented and
                      accounted for. Water content was assessed for whole brain,
                      grey and white matter and more specifically for regions
                      known to be affected by acute or chronic alcohol misuse
                      (occipital and frontal lobes, thalamus and pons). Changes in
                      the volume of grey and white matter as well as the whole
                      brain were examined.ResultsQuantitative cerebral water
                      content before and after acute alcohol consumption did not
                      differ significantly (P ≥ 0.07), with changes often being
                      within the range of measurement accuracy. Whole brain, white
                      and grey matter volume did not change significantly (P ≥
                      0.12).ConclusionThe results of our study show no significant
                      water content or volume change in the brain after recent
                      alcohol intake in healthy volunteers. This accounts for the
                      whole brain, grey and white matter, occipital and frontal
                      lobes, thalamus and pons.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34002208},
      UT           = {WOS:000755804100001},
      doi          = {10.1093/alcalc/agab026},
      url          = {https://juser.fz-juelich.de/record/892758},
}