TY  - JOUR
AU  - Popovych, Oleksandr V.
AU  - Jung, Kyesam
AU  - Manos, Thanos
AU  - Diaz-Pier, Sandra
AU  - Hoffstaedter, Felix
AU  - Schreiber, Jan
AU  - Yeo, B. T. Thomas
AU  - Eickhoff, Simon B.
TI  - Inter-subject and inter-parcellation variability of resting-state whole-brain dynamical modeling
JO  - NeuroImage
VL  - 236
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2021-02365
SP  - 118201 -
PY  - 2021
AB  - Modern approaches to investigate complex brain dynamics suggest to represent the brain as a functional network of brain regions defined by a brain atlas, while edges represent the structural or functional connectivity among them. This approach is also utilized for mathematical modeling of the resting-state brain dynamics, where the applied brain parcellation plays an essential role in deriving the model network and governing the modeling results. There is however no consensus and empirical evidence on how a given brain atlas affects the model outcome, and the choice of parcellation is still rather arbitrary. Accordingly, we explore the impact of brain parcellation on inter-subject and inter-parcellation variability of model fitting to empirical data. Our objective is to provide a comprehensive empirical evidence of potential influences of parcellation choice on resting-state whole-brain dynamical modeling. We show that brain atlases strongly influence the quality of model validation and propose several variables calculated from empirical data to account for the observed variability. A few classes of such data variables can be distinguished depending on their inter-subject and inter-parcellation explanatory power.
LB  - PUB:(DE-HGF)16
C6  - 34033913
UR  - <Go to ISI:>//WOS:000670278100013
DO  - DOI:10.1016/j.neuroimage.2021.118201
UR  - https://juser.fz-juelich.de/record/892819
ER  -