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000892852 1001_ $$0P:(DE-Juel1)171961$$aKostritskii, Andrei Y.$$b0$$ufzj
000892852 245__ $$aMolecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
000892852 260__ $$a[London]$$bNature Publishing Group UK$$c2021
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000892852 520__ $$aTMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. However, their molecular mechanisms of ion conduction and selectivity remain largely unknown. Using computational electrophysiology simulations at atomistic resolution, we identified the main ion-conductive state of TMEM16 lipid scramblases, in which an ion permeation pathway is lined by lipid headgroups that directly interact with permeating ions in a voltage polarity-dependent manner. We found that lipid headgroups modulate the ion-permeability state and regulate ion selectivity to varying degrees in different scramblase isoforms, depending on the amino-acid composition of the pores. Our work has defined the structural basis of ion conduction and selectivity in TMEM16 lipid scramblases and uncovered the mechanisms responsible for the direct effects of membrane lipids on the conduction properties of ion channels.
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000892852 536__ $$0G:(DE-Juel1)jics41_20191101$$aMechanisms of Ca2+-activated Cl- channels and lipid scramblases of the TMEM16 family (jics41_20191101)$$cjics41_20191101$$fMechanisms of Ca2+-activated Cl- channels and lipid scramblases of the TMEM16 family$$x1
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000892852 7001_ $$0P:(DE-Juel1)156429$$aMachtens, Jan-Philipp$$b1$$eCorresponding author
000892852 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-021-22724-w$$gVol. 12, no. 1, p. 2826$$n1$$p2826$$tNature Communications$$v12$$x2041-1723$$y2021
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