TY  - JOUR
AU  - van Putten, Michel J. A. M.
AU  - Fahlke, Christoph
AU  - Kafitz, Karl W.
AU  - Hofmeijer, Jeannette
AU  - Rose, Christine R.
TI  - Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage
JO  - International journal of molecular sciences
VL  - 22
IS  - 11
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - FZJ-2021-02406
SP  - 5679 -
PY  - 2021
AB  - Ischemic stroke is a leading cause of mortality and chronic disability. Either recovery or progression towards irreversible failure of neurons and astrocytes occurs within minutes to days, depending on remaining perfusion levels. Initial damage arises from energy depletion resulting in a failure to maintain homeostasis and ion gradients between extra- and intracellular spaces. Astrocytes play a key role in these processes and are thus central players in the dynamics towards recovery or progression of stroke-induced brain damage. Here, we present a synopsis of the pivotal functions of astrocytes at the tripartite synapse, which form the basis of physiological brain functioning. We summarize the evidence of astrocytic failure and its consequences under ischemic conditions. Special emphasis is put on the homeostasis and stroke-induced dysregulation of the major monovalent ions, namely Na+, K+, H+, and Cl-, and their involvement in maintenance of cellular volume and generation of cerebral edema. 
LB  - PUB:(DE-HGF)16
C6  - 34073593
UR  - <Go to ISI:>//WOS:000660219900001
DO  - DOI:10.3390/ijms22115679
UR  - https://juser.fz-juelich.de/record/892867
ER  -