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@ARTICLE{Mullins:892948,
      author       = {Mullins, Niamh and Forstner, Andreas J and O'Connell, Kevin
                      S and Coombes, Brandon and Coleman, Jonathan R I and Qiao,
                      Zhen and Als, Thomas D and Bigdeli, Tim B and Børte, Sigrid
                      and Bryois, Julien and Charney, Alexander W and Drange, Ole
                      Kristian and Gandal, Michael J and Hagenaars, Saskia P and
                      Ikeda, Masashi and Kamitaki, Nolan and Kim, Minsoo and
                      Krebs, Kristi and Panagiotaropoulou, Georgia and Schilder,
                      Brian M and Sloofman, Laura G and Steinberg, Stacy and
                      Trubetskoy, Vassily and Winsvold, Bendik S and Won, Hong-Hee
                      and Abramova, Liliya and Adorjan, Kristina and Agerbo, Esben
                      and Al Eissa, Mariam and Albani, Diego and Alliey-Rodriguez,
                      Ney and Anjorin, Adebayo and Antilla, Verneri and Antoniou,
                      Anastasia and Awasthi, Swapnil and Baek, Ji Hyun and
                      Bækvad-Hansen, Marie and Bass, Nicholas and Bauer, Michael
                      and Beins, Eva C and Bergen, Sarah E and Birner, Armin and
                      Bøcker Pedersen, Carsten and Bøen, Erlend and Boks, Marco
                      P and Bosch, Rosa and Brum, Murielle and Brumpton, Ben M and
                      Brunkhorst-Kanaan, Nathalie and Budde, Monika and
                      Bybjerg-Grauholm, Jonas and Byerley, William and Cairns,
                      Murray and Casas, Miquel and Cervantes, Pablo and Clarke,
                      Toni-Kim and Cruceanu, Cristiana and Cuellar-Barboza,
                      Alfredo and Cunningham, Julie and Curtis, David and Czerski,
                      Piotr M and Dale, Anders M and Dalkner, Nina and David,
                      Friederike S and Degenhardt, Franziska and Djurovic, Srdjan
                      and Dobbyn, Amanda L and Douzenis, Athanassios and
                      Elvsåshagen, Torbjørn and Escott-Price, Valentina and
                      Ferrier, I Nicol and Fiorentino, Alessia and Foroud, Tatiana
                      M and Forty, Liz and Frank, Josef and Frei, Oleksandr and
                      Freimer, Nelson B and Frisén, Louise and Gade, Katrin and
                      Garnham, Julie and Gelernter, Joel and Giørtz Pedersen,
                      Marianne and Gizer, Ian R and Gordon, Scott D and
                      Gordon-Smith, Katherine and Greenwood, Tiffany A and Grove,
                      Jakob and Guzman-Parra, José and Ha, Kyooseob and
                      Haraldsson, Magnus and Hautzinger, Martin and Heilbronner,
                      Urs and Hellgren, Dennis and Herms, Stefan and Hoffmann, Per
                      and Holmans, Peter A and Huckins, Laura and Jamain,
                      Stéphane and Johnson, Jessica S and Kalman, Janos L and
                      Kamatani, Yoichiro and Kennedy, James L and
                      Kittel-Schneider, Sarah and Knowles, James A and Kogevinas,
                      Manolis and Koromina, Maria and Kranz, Thorsten M and
                      Kranzler, Henry R and Kubo, Michiaki and Kupka, Ralph and
                      Kushner, Steven A and Lavebratt, Catharina and Lawrence,
                      Jacob and Leber, Markus and Lee, Heon-Jeong and Lee, Phil H
                      and Levy, Shawn E and Lewis, Catrin and Liao, Calwing and
                      Lucae, Susanne and Lundberg, Martin and MacIntyre, Donald J
                      and Magnusson, Sigurdur H and Maier, Wolfgang and Maihofer,
                      Adam and Malaspina, Dolores and Maratou, Eirini and
                      Martinsson, Lina and Mattheisen, Manuel and McCarroll,
                      Steven A and McGregor, Nathaniel W and McGuffin, Peter and
                      McKay, James D and Medeiros, Helena and Medland, Sarah E and
                      Millischer, Vincent and Montgomery, Grant W and Moran,
                      Jennifer L and Morris, Derek W and Mühleisen, Thomas W and
                      O'Brien, Niamh and O'Donovan, Claire and Olde Loohuis, Loes
                      M and Oruc, Lilijana and Papiol, Sergi and Pardiñas,
                      Antonio F and Perry, Amy and Pfennig, Andrea and Porichi,
                      Evgenia and Potash, James B and Quested, Digby and Raj,
                      Towfique and Rapaport, Mark H and DePaulo, J Raymond and
                      Regeer, Eline J and Rice, John P and Rivas, Fabio and
                      Rivera, Margarita and Roth, Julian and Roussos, Panos and
                      Ruderfer, Douglas M and Sánchez-Mora, Cristina and Schulte,
                      Eva C and Senner, Fanny and Sharp, Sally and Shilling, Paul
                      D and Sigurdsson, Engilbert and Sirignano, Lea and Slaney,
                      Claire and Smeland, Olav B and Smith, Daniel J and Sobell,
                      Janet L and Søholm Hansen, Christine and Soler Artigas,
                      Maria and Spijker, Anne T and Stein, Dan J and Strauss, John
                      S and Świątkowska, Beata and Terao, Chikashi and
                      Thorgeirsson, Thorgeir E and Toma, Claudio and Tooney, Paul
                      and Tsermpini, Evangelia-Eirini and Vawter, Marquis P and
                      Vedder, Helmut and Walters, James T R and Witt, Stephanie H
                      and Xi, Simon and Xu, Wei and Yang, Jessica Mei Kay and
                      Young, Allan H and Young, Hannah and Zandi, Peter P and
                      Zhou, Hang and Zillich, Lea and Psychiatry, HUNT All-In and
                      Adolfsson, Rolf and Agartz, Ingrid and Alda, Martin and
                      Alfredsson, Lars and Babadjanova, Gulja and Backlund, Lena
                      and Baune, Bernhard T and Bellivier, Frank and Bengesser,
                      Susanne and Berrettini, Wade H and Blackwood, Douglas H R
                      and Boehnke, Michael and Børglum, Anders D and Breen,
                      Gerome and Carr, Vaughan J and Catts, Stanley and Corvin,
                      Aiden and Craddock, Nicholas and Dannlowski, Udo and Dikeos,
                      Dimitris and Esko, Tõnu and Etain, Bruno and Ferentinos,
                      Panagiotis and Frye, Mark and Fullerton, Janice M and
                      Gawlik, Micha and Gershon, Elliot S and Goes, Fernando S and
                      Green, Melissa J and Grigoroiu-Serbanescu, Maria and Hauser,
                      Joanna and Henskens, Frans and Hillert, Jan and Hong, Kyung
                      Sue and Hougaard, David M and Hultman, Christina M and
                      Hveem, Kristian and Iwata, Nakao and Jablensky, Assen V and
                      Jones, Ian and Jones, Lisa A and Kahn, René S and Kelsoe,
                      John R and Kirov, George and Landén, Mikael and Leboyer,
                      Marion and Lewis, Cathryn M and Li, Qingqin S and Lissowska,
                      Jolanta and Lochner, Christine and Loughland, Carmel and
                      Martin, Nicholas G and Mathews, Carol A and Mayoral, Fermin
                      and McElroy, Susan L and McIntosh, Andrew M and McMahon,
                      Francis J and Melle, Ingrid and Michie, Patricia and Milani,
                      Lili and Mitchell, Philip B and Morken, Gunnar and Mors, Ole
                      and Mortensen, Preben Bo and Mowry, Bryan and
                      Müller-Myhsok, Bertram and Myers, Richard M and Neale,
                      Benjamin M and Nievergelt, Caroline M and Nordentoft, Merete
                      and Nöthen, Markus M and O'Donovan, Michael C and
                      Oedegaard, Ketil J and Olsson, Tomas and Owen, Michael J and
                      Paciga, Sara A and Pantelis, Chris and Pato, Carlos and
                      Pato, Michele T and Patrinos, George P and Perlis, Roy H and
                      Posthuma, Danielle and Ramos-Quiroga, Josep Antoni and Reif,
                      Andreas and Reininghaus, Eva Z and Ribasés, Marta and
                      Rietschel, Marcella and Ripke, Stephan and Rouleau, Guy A
                      and Saito, Takeo and Schall, Ulrich and Schalling, Martin
                      and Schofield, Peter R and Schulze, Thomas G and Scott,
                      Laura J and Scott, Rodney J and Serretti, Alessandro and
                      Shannon Weickert, Cynthia and Smoller, Jordan W and
                      Stefansson, Hreinn and Stefansson, Kari and Stordal, Eystein
                      and Streit, Fabian and Sullivan, Patrick F and Turecki,
                      Gustavo and Vaaler, Arne E and Vieta, Eduard and Vincent,
                      John B and Waldman, Irwin D and Weickert, Thomas W and
                      Werge, Thomas and Wray, Naomi R and Zwart, John-Anker and
                      Biernacka, Joanna M and Nurnberger, John I and Cichon, Sven
                      and Edenberg, Howard J and Stahl, Eli A and McQuillin,
                      Andrew and Di Florio, Arianna and Ophoff, Roel A and
                      Andreassen, Ole A},
      title        = {{G}enome-wide association study of more than 40,000 bipolar
                      disorder cases provides new insights into the underlying
                      biology.},
      journal      = {Nature genetics},
      volume       = {53},
      number       = {6},
      issn         = {1546-1718},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-02447},
      pages        = {817-829},
      year         = {2021},
      abstract     = {Bipolar disorder is a heritable mental illness with complex
                      etiology. We performed a genome-wide association study of
                      41,917 bipolar disorder cases and 371,549 controls of
                      European ancestry, which identified 64 associated genomic
                      loci. Bipolar disorder risk alleles were enriched in genes
                      in synaptic signaling pathways and brain-expressed genes,
                      particularly those with high specificity of expression in
                      neurons of the prefrontal cortex and hippocampus.
                      Significant signal enrichment was found in genes encoding
                      targets of antipsychotics, calcium channel blockers,
                      antiepileptics and anesthetics. Integrating expression
                      quantitative trait locus data implicated 15 genes robustly
                      linked to bipolar disorder via gene expression, encoding
                      druggable targets such as HTR6, MCHR1, DCLK3 and FURIN.
                      Analyses of bipolar disorder subtypes indicated high but
                      imperfect genetic correlation between bipolar disorder type
                      I and II and identified additional associated loci.
                      Together, these results advance our understanding of the
                      biological etiology of bipolar disorder, identify novel
                      therapeutic leads and prioritize genes for functional
                      follow-up studies.},
      cin          = {INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34002096},
      UT           = {WOS:000651382200001},
      doi          = {10.1038/s41588-021-00857-4},
      url          = {https://juser.fz-juelich.de/record/892948},
}