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@ARTICLE{Mack:893078,
      author       = {Mack, Kevin and Doeker, Moritz and Grabowski, Laura and
                      Jupke, Andreas and Rother, Dörte},
      title        = {{E}xtractive in-situ product removal for the application of
                      naturally produced {L}-alanine as amine donor in enzymatic
                      metaraminol production},
      journal      = {Green chemistry},
      volume       = {23},
      number       = {13},
      issn         = {1463-9270},
      address      = {Cambridge},
      publisher    = {RSC},
      reportid     = {FZJ-2021-02546},
      pages        = {4892-4901},
      year         = {2021},
      abstract     = {Vicinal amino alcohols such as metaraminol find direct
                      application in pharmaceuticals and serve as building blocks
                      for fine chemicals. The amine transaminase enzyme can
                      facilitate the stereoselective production of such amino
                      alcohols, which have two chiral centers, e.g. by
                      transamination from 2-hydroxy ketones in the presence of an
                      amine donor. The feasibility of enzymatic metaraminol
                      production has already been demonstrated with the amine
                      donor isopropylamine. This amine donor has the drawback of
                      an unfavorable reaction equilibrium for the target reaction
                      and being crude oil-based. Therefore, we substituted
                      isopropylamine with the bio-based amine donor L-alanine. As
                      the transamination reaction is also thermodynamically
                      limited when utilizing L-alanine, in situ liquid–liquid
                      extraction of metaraminol can solve this drawback and was
                      implemented to increase the conversions and initiate
                      downstream processing steps. We investigated a suitable
                      solvent–enzyme combination and determined a distinct
                      operational window in terms of reaction conditions for
                      combining the enzymatic metaraminol production with product
                      extraction in a smart process concept. This study thus
                      presents a powerful example for the use of the bio-based
                      amine donor L-alanine in combination with efficient process
                      intensification of biocatalytic drug synthesis by means of
                      in situ product removal.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000664600800001},
      doi          = {10.1039/D1GC00852H},
      url          = {https://juser.fz-juelich.de/record/893078},
}