% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Apetz:893080,
      author       = {Apetz, Nadine and Paralikar, Kunal and Neumaier, Bernd and
                      Drzezga, Alexander and Wiedermann, Dirk and Iyer, Rajesh and
                      Munns, Gordon and Scott, Erik and Timmermann, Lars and
                      Endepols, Heike},
      title        = {{T}owards chronic deep brain stimulation in freely moving
                      hemiparkinsonian rats: applicability and functionality of a
                      fully implantable stimulation system},
      journal      = {Journal of neural engineering},
      volume       = {18},
      number       = {3},
      issn         = {1741-2552},
      address      = {Bristol},
      publisher    = {Institute of Physics Publishing},
      reportid     = {FZJ-2021-02548},
      pages        = {036018},
      year         = {2021},
      abstract     = {This study aimed at investigating a novel fully implantable
                      deep brain stimulation(DBS) system and its ability to
                      modulate brain metabolism and behavior through
                      subthalamicnucleus (STN) stimulation in a hemiparkinsonian
                      rat model.Approach.Twelve male rats wereunilaterally
                      lesioned with 6-hydroxydopamine in the medial forebrain
                      bundle and received a fullyimplantable DBS system aiming at
                      the ipsilesional STN. Each rat underwent three cylinder
                      tests toanalyze front paw use: a PRE test before any
                      surgical intervention, an OFF test after surgery butbefore
                      stimulation onset and an ON test under DBS. To visualize
                      brain glucose metabolism in theawake animal, two [18F]FDG
                      scans were conducted in the OFF and ON condition. At least 4
                      weeksafter surgery, an [18F]FDOPA scan was used to check for
                      dopaminergic integrity.Main results.Ingeneral, STN DBS
                      increased [18F]FDG uptake ipsilesionally and decreased it
                      contralesionally. Morespecifically, bilateral orbitofrontal
                      cortex, ipsilateral caudate putamen, sensorimotor cortex
                      andnucleus accumbens showed significantly higher tracer
                      uptake in ON compared to OFF condition.Contralateral
                      cingulate and secondary motor cortex, caudate putamen,
                      amygdala, hippocampus,retrosplenial granular cortex,
                      superior colliculus, and parts of the cerebellum
                      exhibitedsignificantly higher [18F]FDG uptake in the OFF
                      condition. On the behavioral level, stimulationwas able
                      improve use of the contralesional affected front paw
                      suggesting an effective stimulationproduced by the implanted
                      system.Significance.The fully implantable stimulation
                      systemdeveloped by us and presented here offers the output
                      of arbitrary user-defined waveforms, patternsand stimulation
                      settings and allows tracer accumulation in freely moving
                      animals. It is therefore asuitable device for implementing
                      behavioral PET studies. It contributes immensely to
                      thepossibilities to characterize and unveil the effects and
                      mechanisms of DBS offering valuable cluesfor future
                      improvements of this therapy},
      cin          = {INM-5 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33607640},
      UT           = {WOS:000629524500001},
      doi          = {10.1088/1741-2552/abe806},
      url          = {https://juser.fz-juelich.de/record/893080},
}