TY  - JOUR
AU  - Liang, Yuanying
AU  - Offenhäusser, Andreas
AU  - Ingebrandt, Sven
AU  - Mayer, Dirk
TI  - PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals
JO  - Advanced healthcare materials
VL  - 10
IS  - 11
SN  - 2192-2659
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2021-02568
SP  - 2100061
PY  - 2021
AB  - To understand the physiology and pathology of electrogenic cells and the corresponding tissue in their full complexity, the quantitative investigation of the transmission of ions as well as the release of chemical signals is important. Organic (semi-) conducting materials and in particular organic electrochemical transistor are gaining in importance for the investigation of electrophysiological and recently biochemical signals due to their synthetic nature and thus chemical diversity and modifiability, their biocompatible and compliant properties, as well as their mixed electronic and ionic conductivity featuring ion-to-electron conversion. Here, the aim is to summarize recent progress on the development of bioelectronic devices utilizing polymer polyethylenedioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) to interface electronics and biological matter including microelectrode arrays, neural cuff electrodes, organic electrochemical transistors, PEDOT:PSS-based biosensors, and organic electronic ion pumps. Finally, progress in the material development is summarized for the improvement of polymer conductivity, stretchability, higher transistor transconductance, or to extend their field of application such as cation sensing or metabolite recognition. This survey of recent trends in PEDOT:PSS electrophysiological sensors highlights the potential of this multifunctional material to revolve current technology and to enable long-lasting, multichannel polymer probes for simultaneous recordings of electrophysiological and biochemical signals from electrogenic cells.
LB  - PUB:(DE-HGF)16
C6  - 33970552
UR  - <Go to ISI:>//WOS:000648612900001
DO  - DOI:10.1002/adhm.202100061
UR  - https://juser.fz-juelich.de/record/893110
ER  -