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001     893110
005     20230303100115.0
024 7 _ |a 10.1002/adhm.202100061
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037 _ _ |a FZJ-2021-02568
082 _ _ |a 610
100 1 _ |a Liang, Yuanying
|0 P:(DE-Juel1)168271
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245 _ _ |a PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals
260 _ _ |a Weinheim
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|b Wiley-VCH
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520 _ _ |a To understand the physiology and pathology of electrogenic cells and the corresponding tissue in their full complexity, the quantitative investigation of the transmission of ions as well as the release of chemical signals is important. Organic (semi-) conducting materials and in particular organic electrochemical transistor are gaining in importance for the investigation of electrophysiological and recently biochemical signals due to their synthetic nature and thus chemical diversity and modifiability, their biocompatible and compliant properties, as well as their mixed electronic and ionic conductivity featuring ion-to-electron conversion. Here, the aim is to summarize recent progress on the development of bioelectronic devices utilizing polymer polyethylenedioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) to interface electronics and biological matter including microelectrode arrays, neural cuff electrodes, organic electrochemical transistors, PEDOT:PSS-based biosensors, and organic electronic ion pumps. Finally, progress in the material development is summarized for the improvement of polymer conductivity, stretchability, higher transistor transconductance, or to extend their field of application such as cation sensing or metabolite recognition. This survey of recent trends in PEDOT:PSS electrophysiological sensors highlights the potential of this multifunctional material to revolve current technology and to enable long-lasting, multichannel polymer probes for simultaneous recordings of electrophysiological and biochemical signals from electrogenic cells.
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700 1 _ |a Offenhäusser, Andreas
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700 1 _ |a Ingebrandt, Sven
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700 1 _ |a Mayer, Dirk
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|e Corresponding author
773 _ _ |a 10.1002/adhm.202100061
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