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@ARTICLE{KumarPandey:893166,
      author       = {Kumar Pandey, Abhishek and Piplani, Niyati and Mondal,
                      Titas and Katranidis, Alexandros and Bhattacharya, Jaydeep},
      title        = {{E}fficient delivery of hydrophobic drug, {C}abazitaxel,
                      using {N}anodisc: {A} {N}ano sized free standing planar
                      lipid bilayer},
      journal      = {Journal of molecular liquids},
      volume       = {339},
      issn         = {0167-7322},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-02604},
      pages        = {116690 -},
      year         = {2021},
      abstract     = {Several new drug candidates have emerged as potential
                      cancer therapeutics with the advent of drug discovery. The
                      hydrophilic drug candidates have easily translated to
                      chemotherapy via oral or intravenous administration methods,
                      whereas efficient drug delivery vehicles for hydrophobic
                      drugs have been an area of concern. This has resulted in an
                      increasing interest in the nano-sized polymer and
                      lipid-based drug delivery systems due to their enhanced
                      distribution, bioavailability, and therapeutic value. In
                      this study, the efficiency of membrane scaffold protein
                      (MSP) embedded POPC
                      (1-palmitoyl-2-oleoyl-glycero-3-phosphocholine) nanodiscs
                      has been investigated as a hydrophobic drug delivery
                      vehicle. Synthesized nanodiscs with an average diameter of
                      27.03 ± 1.5 nm were loaded with different hydrophobic drugs
                      and evaluated for biocompatibility and drug release
                      kinetics. The drug loading was found to be proportional to
                      the hydrophobicity (LogP) of the drugs. Drug loaded
                      nanodiscs showed sustained drug release till 24 h which was
                      preceded by initial burst release. Drug delivery efficacy of
                      cabazitaxel loaded nanodiscs (NDCBT) was tested by in vitro
                      cytotoxicity assay, cell cycle arrest analysis, and spheroid
                      growth inhibition study. We achieved significant enhancement
                      of autophagy mediated cell death using NDCBTs when compared
                      to free drug. Similarly, NDCBTs were able to induce
                      approximately $20\%$ higher toxicity in 3D spheroids model.},
      cin          = {IBI-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-6-20200312},
      pnm          = {5352 - Understanding the Functionality of Soft Matter and
                      Biomolecular Systems (POF4-535) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5352 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000691312600020},
      doi          = {10.1016/j.molliq.2021.116690},
      url          = {https://juser.fz-juelich.de/record/893166},
}