% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Frieg:893207,
      author       = {Frieg, Benedikt and Görg, Boris and Gohlke, Holger and
                      Häussinger, Dieter},
      title        = {{G}lutamine synthetase as a central element in hepatic
                      glutamine and ammonia metabolism: novel aspects},
      journal      = {Biological chemistry},
      volume       = {402},
      number       = {9},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2021-02624},
      pages        = {1063-1072},
      year         = {2021},
      abstract     = {Glutamine synthetase (GS) in the liver is expressed in a
                      small perivenous, highly specializedhepatocyte population
                      and is essential for the maintenance of low, non‐toxic
                      ammonia levelsin the organism. However, GS activity can be
                      impaired by tyrosine nitration of the enzyme inresponse to
                      oxidative/nitrosative stress in a pH‐sensitive way. The
                      underlying molecularmechanism as investigated by combined
                      molecular simulations and in vitro experimentsindicates that
                      tyrosine nitration can lead to a fully reversible and
                      pH‐sensitive regulation ofprotein function. This approach
                      was also used to understand the functional consequences
                      ofseveral recently described point mutations of human GS
                      with clinical relevance and to suggestan approach to restore
                      impaired GS activity.},
      cin          = {IBG-4 / NIC / JSC / IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-4-20200403 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / 2171 - Biological
                      and environmental resources for sustainable use (POF4-217) /
                      2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217) / 511 -
                      Computational Science and Mathematical Methods (POF3-511)},
      pid          = {G:(DE-HGF)POF4-5111 / G:(DE-HGF)POF4-2171 /
                      G:(DE-HGF)POF4-2172 / G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33962502},
      UT           = {WOS:000685568800006},
      doi          = {10.1515/hsz-2021-0166},
      url          = {https://juser.fz-juelich.de/record/893207},
}