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000893209 1001_ $$0P:(DE-HGF)0$$aPrescher, Martin$$b0
000893209 245__ $$aEvidence for a credit-card-swipe mechanism in the human PC floppase ABCB4
000893209 260__ $$aCambridge, Mass.$$bCell Press$$c2021
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000893209 520__ $$aABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs. The high degree of amino acid identity of 76% for ABCB4 and ABCB1, which is a prototype multidrug-resistance-mediating protein, results in ABCB4's second subset of substrates, which overlap with ABCB1's substrates. This often leads to incomplete annotations of ABCB4, in which it was described as exclusively PC-lipid specific. When the hydrophilic amino acids from ABCB4 are changed to the analogous but hydrophobic ones from ABCB1, the stimulation of ATPase activity by 1,2-dioleoyl-sn-glycero-3-phosphocholine, as a prime example of PC lipids, is strongly diminished, whereas the modulation capability of ABCB1 substrates remains unchanged. This indicates two distinct and autonomous substrate binding sites in ABCB4.
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000893209 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000893209 7001_ $$00000-0003-4411-7342$$aBonus, Michele$$b1
000893209 7001_ $$00000-0002-8760-1989$$aStindt, Jan$$b2
000893209 7001_ $$0P:(DE-HGF)0$$aKeitel-Anselmino, Verena$$b3
000893209 7001_ $$0P:(DE-HGF)0$$aSmits, Sander H. J.$$b4
000893209 7001_ $$0P:(DE-Juel1)172663$$aGohlke, Holger$$b5$$ufzj
000893209 7001_ $$0P:(DE-HGF)0$$aSchmitt, Lutz$$b6$$eCorresponding author
000893209 773__ $$0PERI:(DE-600)2031189-8$$a10.1016/j.str.2021.05.013$$gp. S0969212621001714$$n10$$p1144-1155.e5$$tStructure$$v29$$x0969-2126$$y2021
000893209 8564_ $$uhttps://juser.fz-juelich.de/record/893209/files/Manuscript_modified_MP_HG.pdf$$yPublished on 2021-06-08. Available in OpenAccess from 2022-06-08.
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