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@ARTICLE{Prescher:893209,
      author       = {Prescher, Martin and Bonus, Michele and Stindt, Jan and
                      Keitel-Anselmino, Verena and Smits, Sander H. J. and Gohlke,
                      Holger and Schmitt, Lutz},
      title        = {{E}vidence for a credit-card-swipe mechanism in the human
                      {PC} floppase {ABCB}4},
      journal      = {Structure},
      volume       = {29},
      number       = {10},
      issn         = {0969-2126},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {FZJ-2021-02626},
      pages        = {1144-1155.e5},
      year         = {2021},
      abstract     = {ABCB4 is described as an ATP-binding cassette (ABC)
                      transporter that primarily transports lipids of the
                      phosphatidylcholine (PC) family but is also capable of
                      translocating a subset of typical
                      multidrug-resistance-associated drugs. The high degree of
                      amino acid identity of $76\%$ for ABCB4 and ABCB1, which is
                      a prototype multidrug-resistance-mediating protein, results
                      in ABCB4's second subset of substrates, which overlap with
                      ABCB1's substrates. This often leads to incomplete
                      annotations of ABCB4, in which it was described as
                      exclusively PC-lipid specific. When the hydrophilic amino
                      acids from ABCB4 are changed to the analogous but
                      hydrophobic ones from ABCB1, the stimulation of ATPase
                      activity by 1,2-dioleoyl-sn-glycero-3-phosphocholine, as a
                      prime example of PC lipids, is strongly diminished, whereas
                      the modulation capability of ABCB1 substrates remains
                      unchanged. This indicates two distinct and autonomous
                      substrate binding sites in ABCB4.},
      cin          = {IBG-4 / NIC / JSC / IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-4-20200403 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / 2171 - Biological and environmental resources
                      for sustainable use (POF4-217) / 2172 - Utilization of
                      renewable carbon and energy sources and engineering of
                      ecosystem functions (POF4-217) / 5111 - Domain-Specific
                      Simulation $\&$ Data Life Cycle Labs (SDLs) and Research
                      Groups (POF4-511) / Forschergruppe Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF3-511 / G:(DE-HGF)POF4-2171 /
                      G:(DE-HGF)POF4-2172 / G:(DE-HGF)POF4-5111 /
                      $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34107287},
      UT           = {WOS:000743716700006},
      doi          = {10.1016/j.str.2021.05.013},
      url          = {https://juser.fz-juelich.de/record/893209},
}