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@ARTICLE{Dong:893215,
      author       = {Dong, Debo and Yao, Dezhong and Wang, Yulin and Hong,
                      Seok-Jun and Genon, Sarah and Xin, Fei and Jung, Kyesam and
                      He, Hui and Chang, Xuebin and Duan, Mingjun and Bernhardt,
                      Boris C. and Margulies, Daniel S. and Sepulcre, Jorge and
                      Eickhoff, Simon B. and Luo, Cheng},
      title        = {{C}ompressed sensorimotor-to-transmodal hierarchical
                      organization in schizophrenia},
      journal      = {Psychological medicine},
      volume       = {-},
      issn         = {1469-8978},
      address      = {[S.l.]},
      publisher    = {Proquest},
      reportid     = {FZJ-2021-02632},
      pages        = {1 - 14},
      year         = {2021},
      note         = {Published online by Cambridge University Press: 08 June
                      2021},
      abstract     = {Background: Schizophrenia has been primarily conceptualized
                      as a disorder of high-order cognitive functions with
                      deficits in executive brain regions. Yet due to the
                      increasing reports of early sensory processing deficit,
                      recent models focus more on the developmental effects of
                      impaired sensory process on high-order functions. The
                      present study examined whether this pathological interaction
                      relates to an overarching system-level imbalance,
                      specifically a disruption in macroscale hierarchy affecting
                      integration and segregation of unimodal and transmodal
                      networks.Methods: We applied a novel combination of
                      connectome gradient and stepwise connectivity analysis to
                      resting-state fMRI to characterize the
                      sensorimotor-to-transmodal cortical hierarchy organization
                      (96 patients v. 122 controls).Results: We demonstrated
                      compression of the cortical hierarchy organization in
                      schizophrenia, with a prominent compression from the
                      sensorimotor region and a less prominent compression from
                      the frontal-parietal region, resulting in a diminished
                      separation between sensory and fronto-parietal cognitive
                      systems. Further analyses suggested reduced differentiation
                      related to atypical functional connectome transition from
                      unimodal to transmodal brain areas. Specifically, we found
                      hypo-connectivity within unimodal regions and
                      hyper-connectivity between unimodal regions and
                      fronto-parietal and ventral attention regions along the
                      classical sensation-to-cognition continuum (voxel-level
                      corrected, p < 0.05).Conclusions: The compression of
                      cortical hierarchy organization represents a novel and
                      integrative system-level substrate underlying the
                      pathological interaction of early sensory and cognitive
                      function in schizophrenia. This abnormal cortical hierarchy
                      organization suggests cascading impairments from the
                      disruption of the somatosensory-motor system and inefficient
                      integration of bottom-up sensory information with
                      attentional demands and executive control processes
                      partially account for high-level cognitive deficits
                      characteristic of schizophrenia.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34100349},
      UT           = {WOS:000786199000001},
      doi          = {10.1017/S0033291721002129},
      url          = {https://juser.fz-juelich.de/record/893215},
}