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@ARTICLE{Dietlein:893306,
      author       = {Dietlein, Felix and Mueller, Peter and Kobe, Carsten and
                      Endepols, Heike and Hohberg, Melanie and Zlatopolskiy, Boris
                      and Krapf, Philipp and Heidenreich, Axel and Neumaier, Bernd
                      and Drzezga, Alexander and Dietlein, Markus},
      title        = {[18{F}]-{JK}-{PSMA}-7 {PET}/{CT} {U}nder {A}ndrogen
                      {D}eprivation {T}herapy in {A}dvanced {P}rostate {C}ancer},
      journal      = {Molecular imaging and biology},
      volume       = {23},
      number       = {2},
      issn         = {1536-1632},
      address      = {Cham},
      publisher    = {Springer Nature Switzerland},
      reportid     = {FZJ-2021-02680},
      pages        = {277-286},
      year         = {2021},
      abstract     = {Purpose: PSMA imaging is frequently used for monitoring of
                      androgen deprivation therapy(ADT) in prostate cancer. In a
                      previous study, [18F]-JK-PSMA-7 exhibited favorable
                      propertiesfor tumor localization after biochemical
                      recurrence. In this retrospective study, we evaluated
                      theperformance of [18F]-JK-PSMA-7 under ADT.Procedures: We
                      examined the performance of [18F]-JK-PSMA-7 in 70 patients
                      (first cohort) withincreasing or detectable PSA values under
                      ADT (PSA G 2 ng/ml for 21/70 patients). We furtheranalyzed
                      58 independent patients with PSA levels G 2 ng/ml under ADT,
                      who were imaged with[68Ga]PSMA-11 or [18F]DCFPyL (second
                      cohort). Finally, we compared detection rates
                      between[18F]-JK-PSMA-7, [68Ga]PSMA-11, and
                      [18F]DCFPyL.Results: In the first cohort, we detected
                      [18F]-JK-PSMA-7-positive lesions in 63/70 patients.
                      Inpatients with PSA levels ≥ 2 ng/ml, the detection rate
                      was 100 $\%$ (49/49). In patients with PSA G 2ng/ml, the
                      detection rate was significantly lower (66.7 $\%,$ 14/21, p
                      = 9.7 × 10−5) and dropped $from85.7\%(12/14,$ PSA levels
                      between 0.3 and 2.0 ng/ml) to $28.6\%(2/7)$ for PSA levels G
                      0.3 ng/ml (p =1.73 × 10−2). In the second cohort (PSA G 2
                      ng/ml), the detection rate was 79.3 $\%$ (46/58)
                      for[68Ga]PSMA-11 or [18F]DCFPyL. Again, the detection rate
                      was significantly higher (p = 1.1 × 10−2)for patients
                      with PSA levels between 0.3 and 2.0 ng/ml (87.0 $\%,$ 40/46)
                      relative to those with PSAlevels G 0.3 ng/ml (50 $\%,$
                      6/12). No significant difference was found between
                      [18F]-JK-PSMA-7 and[68Ga]PSMA-11 or [18F]DCFPyL in patients
                      with PSA levels G 2 ng/ml (p = 0.4295).Conclusion:
                      [18F]-JK-PSMA-7 PET showed a high detection rate in patients
                      with PSA levels ≥0.3 ng/ml under ADT. The lower PSA
                      threshold of 0.3 ng/ml for high detection rates
                      wasconsistent across the three PSMA ligands. Thus, PSMA
                      imaging is suitable for clinical follow-upof patients with
                      increasing PSA levels under ADT.},
      cin          = {INM-5 / INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33006028},
      UT           = {WOS:000574311700001},
      doi          = {10.1007/s11307-020-01546-0},
      url          = {https://juser.fz-juelich.de/record/893306},
}