% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Cui:893315,
      author       = {Cui, Di and Mesaros, Andrea and Burdeos, Gregor and Voigt,
                      Ingo and Giavalisco, Patrick and Hinze, Yvonne and Purrio,
                      Martin and Neumaier, Bernd and Drzezga, Alexander and Obata,
                      Yayoi and Endepols, Heike and Xu, Xiangru},
      title        = {{D}nmt3a2/{D}nmt3{L} {O}verexpression in the {D}opaminergic
                      {S}ystem of {M}ice {I}ncreases {E}xercise {B}ehavior through
                      {S}ignaling {C}hanges in the {H}ypothalamus},
      journal      = {International journal of molecular sciences},
      volume       = {21},
      number       = {17},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2021-02689},
      pages        = {6297 -},
      year         = {2020},
      abstract     = {Dnmt3a2, a de novo DNA methyltransferase, is induced by
                      neuronal activity and participates in long-term memory
                      formation with the increased expression of synaptic
                      plasticity genes. We wanted to determine if Dnmt3a2 with its
                      partner Dnmt3L may influence motor behavior via the
                      dopaminergic system. To this end, we generated a mouse line,
                      Dnmt3a2/3LDat/wt, with dopamine transporter (DAT) promotor
                      driven Dnmt3a2/3L overexpression. The mice were studied with
                      behavioral paradigms (e.g., cylinder test, open field, and
                      treadmill), brain slice patch clamp recordings, ex vivo
                      metabolite analysis, and in vivo positron emission
                      tomography (PET) using the dopaminergic tracer 6-[18F]FMT.
                      The results showed that spontaneous activity and exercise
                      performance were enhanced in Dnmt3a2/3LDat/wt mice compared
                      to Dnmt3a2/3Lwt/wt controls. Dopaminergic substantia nigra
                      pars compacta neurons of Dnmt3a2/3LDat/wt animals displayed
                      a higher fire frequency and excitability. However, dopamine
                      concentration was not increased in the striatum, and
                      dopamine metabolite concentration was even significantly
                      decreased. Striatal 6-[18F]FMT uptake, reflecting aromatic
                      L-amino acid decarboxylase activity, was the same in
                      Dnmt3a2/3LDat/wt mice and controls. [18F]FDG PET showed that
                      hypothalamic metabolic activity was tightly linked to motor
                      behavior in Dnmt3a2/3LDat/wt mice. Furthermore, dopamine
                      biosynthesis and motor-related metabolic activity were
                      correlated in the hypothalamus. Our findings suggest that
                      Dnmt3a2/3L, when overexpressed in dopaminergic neurons,
                      modulates motor performance via activation of the
                      nigrostriatal pathway. This does not involve increased
                      dopamine synthesis.},
      cin          = {INM-5 / INM-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32878077},
      UT           = {WOS:000569576000001},
      doi          = {10.3390/ijms21176297},
      url          = {https://juser.fz-juelich.de/record/893315},
}