TY  - JOUR
AU  - Janouschek, Hildegard
AU  - Chase, Henry W.
AU  - Sharkey, Rachel J.
AU  - Peterson, Zeru J.
AU  - Camilleri, Julia
AU  - Abel, Ted
AU  - Eickhoff, Simon B.
AU  - Nickl-Jockschat, Thomas
TI  - The functional neural architecture of dysfunctional reward processing in autism
JO  - NeuroImage: Clinical
VL  - 31
SN  - 2213-1582
CY  - [Amsterdam u.a.]
PB  - Elsevier
M1  - FZJ-2021-02730
SP  - 102700 -
PY  - 2021
AB  - Functional imaging studies have found differential neural activation patterns during reward-paradigms in patients with autism spectrum disorder (ASD) compared to neurotypical controls. However, publications report conflicting results on the directionality and location of these aberrant activations. We here quantitatively summarized relevant fMRI papers in the field using the anatomical likelihood estimation (ALE) algorithm. Patients with ASD consistently showed hypoactivations in the striatum across studies, mainly in the right putamen and accumbens. These regions are functionally involved in the processing of rewards and are enrolled in extensive neural networks involving limbic, cortical, thalamic and mesencephalic regions. The striatal hypo-activations found in our ALE meta-analysis, which pooled over contrasts derived from the included studies on reward-processing in ASD, highlight the role of the striatum as a key neural correlate of impaired reward processing in autism. These changes were present for studies using social and non-social stimuli alike. The involvement of these regions in extensive networks associated with the processing of both positive and negative emotion alike might hint at broader impairments of emotion processing in the disorder.
LB  - PUB:(DE-HGF)16
C6  - 34161918
UR  - <Go to ISI:>//WOS:000689516300001
DO  - DOI:10.1016/j.nicl.2021.102700
UR  - https://juser.fz-juelich.de/record/893389
ER  -