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@INPROCEEDINGS{Stella:893710,
      author       = {Stella, Alessandra and Bouss, Peter and Palm, Günther and
                      Grün, Sonja},
      title        = {{S}urrogate techniques for testing higher order
                      correlations in parallel spike trains},
      reportid     = {FZJ-2021-02782},
      year         = {2021},
      abstract     = {Spike train surrogates are an essential methodology to
                      assess significance of statistical properties of
                      electrophysiological data. Numerous methods have been
                      already introduced (Date 1998, Gruen et al. 2009, Louis et
                      al. 2010, Pipa et al. 2002,2003,2007, Smith and Kohn 2008,
                      Ricci et al. 2019) and the resulting properties studied in
                      depth, in particular for the case of spike time correlations
                      (Gruen et al. 2009, Louis et al. 2010).The temporal scale of
                      higher-order spike coordination in cortex is still debated
                      in the field (Shadlen and Newsome 1998, London et al. 2010,
                      Mokeichev et al. 2007, Russo et al. 2018, Williams et al.
                      2020). Moreover, it still has to be investigated from which
                      intrinsic statistical characteristics (e.g. firing rate
                      co-modulations, CV, ISI distribution) have influence in the
                      formation of spike patterns. The choice of the surrogate
                      technique is central, since it determines the null
                      hypothesis, where higher order correlation is not a feature
                      of the spike train, i.e. spike trains are mutually
                      independent and only chance correlations are present. For
                      the case of statistical testing for precise temporal
                      correlations, the classical surrogate choice is Uniform
                      Dithering (Date et al. 1998).Here we show a number of
                      problematics arising from the application of Uniform
                      Dithering in the context of testing fine-tune temporal
                      correlation in form of spatio-temporal spike patterns with
                      the SPADE method (Torre et al. 2013/2016, Quaglio et al.
                      2017, Stella et al. 2019). We use already developed
                      surrogate techniques and introduce new ones, and study
                      analytically (when possible) and through simulations the
                      statistical features that are kept and destroyed from
                      surrogate manipulation. Finally, we generate artificial
                      datasets modeled on real experimental data through non
                      stationary point process models, such as Poisson process,
                      Poisson process with dead time (Deger et al. 2011) and Gamma
                      process, comparing the outcome of the SPADE analysis across
                      surrogate techniques.},
      month         = {Jun},
      date          = {2021-06-28},
      organization  = {International Conference of
                       Mathematical Neuroscience, Online
                       (Germany), 28 Jun 2021 - 1 Jul 2021},
      subtyp        = {Invited},
      cin          = {INM-6 / IAS-6 / INM-10},
      cid          = {I:(DE-Juel1)INM-6-20090406 / I:(DE-Juel1)IAS-6-20130828 /
                      I:(DE-Juel1)INM-10-20170113},
      pnm          = {5231 - Neuroscientific Foundations (POF4-523) / 571 -
                      Connectivity and Activity (POF3-571) / HAF - Helmholtz
                      Analytics Framework (ZT-I-0003) / HBP SGA2 - Human Brain
                      Project Specific Grant Agreement 2 (785907) / HBP SGA3 -
                      Human Brain Project Specific Grant Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-5231 / G:(DE-HGF)POF3-571 /
                      G:(DE-HGF)ZT-I-0003 / G:(EU-Grant)785907 /
                      G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/893710},
}