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000893762 245__ $$aStructure-based insights into evolution of rhodopsins
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000893762 520__ $$aRhodopsins, most of which are proton pumps generating transmembrane electrochemical proton gradients, span all three domains of life, are abundant in the biosphere, and could play a crucial role in the early evolution of life on earth. Whereas archaeal and bacterial proton pumps are among the best structurally characterized proteins, rhodopsins from unicellular eukaryotes have not been well characterized. To fill this gap in the current understanding of the proton pumps and to gain insight into the evolution of rhodopsins using a structure-based approach, we performed a structural and functional analysis of the light-driven proton pump LR (Mac) from the pathogenic fungus Leptosphaeria maculans. The first high-resolution structure of fungi rhodopsin and its functional properties reveal the striking similarity of its membrane part to archaeal but not to bacterial rhodopsins. We show that an unusually long N-terminal region stabilizes the protein through direct interaction with its extracellular loop (ECL2). We compare to our knowledge all available structures and sequences of outward light-driven proton pumps and show that eukaryotic and archaeal proton pumps, most likely, share a common ancestor.
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000893762 7001_ $$0P:(DE-HGF)0$$aDmitrieva, Natalia$$b1
000893762 7001_ $$0P:(DE-Juel1)170083$$aVolkov, Oleksandr$$b2
000893762 7001_ $$0P:(DE-HGF)0$$aShevchenko, Vitaly$$b3
000893762 7001_ $$0P:(DE-HGF)0$$aKovalev, Kirill$$b4
000893762 7001_ $$0P:(DE-Juel1)131949$$aBalandin, Taras$$b5
000893762 7001_ $$00000-0001-7945-2218$$aSoloviov, Dmytro$$b6
000893762 7001_ $$0P:(DE-HGF)0$$aAstashkin, Roman$$b7
000893762 7001_ $$0P:(DE-Juel1)174058$$aZinovev, Egor$$b8
000893762 7001_ $$0P:(DE-Juel1)169221$$aAlekseev, Alexey$$b9
000893762 7001_ $$0P:(DE-HGF)0$$aRound, Ekaterina$$b10
000893762 7001_ $$0P:(DE-HGF)0$$aPolovinkin, Vitaly$$b11
000893762 7001_ $$0P:(DE-HGF)0$$aChizhov, Igor$$b12
000893762 7001_ $$0P:(DE-HGF)0$$aRogachev, Andrey$$b13
000893762 7001_ $$0P:(DE-HGF)0$$aOkhrimenko, Ivan$$b14
000893762 7001_ $$0P:(DE-Juel1)179072$$aBorshchevskiy, Valentin$$b15
000893762 7001_ $$0P:(DE-HGF)0$$aChupin, Vladimir$$b16
000893762 7001_ $$0P:(DE-Juel1)131957$$aBüldt, Georg$$b17
000893762 7001_ $$00000-0002-3633-5123$$aYutin, Natalia$$b18
000893762 7001_ $$0P:(DE-HGF)0$$aBamberg, Ernst$$b19
000893762 7001_ $$00000-0003-3943-8299$$aKoonin, Eugene$$b20
000893762 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b21$$eCorresponding author
000893762 773__ $$0PERI:(DE-600)2919698-X$$a10.1038/s42003-021-02326-4$$gVol. 4, no. 1, p. 821$$n1$$p821$$tCommunications biology$$v4$$x2399-3642$$y2021
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